TNF Superfamily (TNFSF) Inhibitors
The TNF Superfamily (TNFSF) signaling involves a group of cytokines and receptors that play crucial roles in inflammation, cell proliferation, survival, and apoptosis. These cytokines, including TNF-alpha and various ligands, bind to their respective TNF receptors, triggering a cascade of intracellular signaling pathways. This activation leads to diverse cellular responses such as the release of inflammatory mediators, immune cell activation, and regulation of apoptotic processes. TNFSF signaling is integral in the immune system's response to infection and injury but can contribute to the pathology of various diseases when dysregulated.
Targeting the TNF Superfamily (TNFSF) for disruption or inhibition involves developing strategies to modulate the interaction between TNF ligands and their receptors. This can be achieved through biological agents like monoclonal antibodies or fusion proteins that specifically bind to TNF cytokines, from activating their receptors. Small molecule inhibitors also play a crucial role by interfering with the signaling pathways downstream of TNF receptor activation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is the most abundant catechin in tea and is known for its antioxidant properties. It might modulate TRAIL expression by interacting with various signaling molecules and transcription factors involved in cell survival and apoptosis. | ||||||
3,3′-Diindolylmethane | 1968-05-4 | sc-204624 sc-204624A sc-204624B sc-204624C sc-204624D sc-204624E | 100 mg 500 mg 5 g 10 g 50 g 1 g | $37.00 $65.00 $89.00 $421.00 $681.00 $66.00 | 8 | |
DIM is a compound found in cruciferous vegetables and is known for its role in supporting detoxification processes. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Found in fruits and nuts, ellagic acid is recognized for its antioxidant properties. It might influence TRAIL expression through its effects on inflammation and cellular defense mechanisms. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $55.00 $114.00 $206.00 $714.00 | 6 | |
Found in milk thistle, silibinin has been researched for its potential liver-protective properties. It may modulate TRAIL expression through its influence on signaling pathways related to liver function and cellular defense. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin is a flavonoid found in various fruits and vegetables, known for its antioxidant properties. It might inhibit TRAIL expression by modulating signaling pathways involved in cell survival and apoptosis. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
I3C is a compound found in cruciferous vegetables and is known for its role in detoxification processes. It may modulate TRAIL expression through its effects on estrogen metabolism and cellular defense mechanisms. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib, a proteasome inhibitor, can affect NF-kB signaling, a pathway that is often activated downstream of TWEAK-Fn14 interaction. By inhibiting NF-kB activation, Bortezomib could indirectly inhibit TWEAK signaling. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Bay 11-7082 inhibits the activation of NF-kB. It could indirectly inhibit TWEAK signaling by reducing the activity of this pathway, which is often involved in TWEAK-mediated cellular responses. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $33.00 $64.00 | 11 | |
PDTC is an antioxidant and inhibitor of NF-kB activation. By inhibiting NF-kB, PDTC could indirectly reduce the signaling effects of TWEAK. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide inhibits NF-kB activation and is also known for its anti-inflammatory properties. Its action on NF-kB could lead to indirect inhibition of TWEAK | ||||||