TNFβ Inhibitors
The chemical class termed TNFβ inhibitors refers to a group of compounds that can interfere with the function of TNFβ, a cytokine involved in immune system regulation and inflammatory processes. The compounds listed operate through a variety of mechanisms, mainly targeting the NF-κB signaling pathway, which is crucial for the transcription of many inflammatory genes, including those related to the TNF family. Inhibition of this pathway results in a decreased expression of various cytokines and can dampen the inflammatory response. Chemicals such as thalidomide, BAY 11-7082, PDTC, parthenolide, curcumin, resveratrol, andrographolide, emodin, isoliquiritigenin, and sulforaphane exhibit their inhibitory effects by preventing the activation of NF-κB, which in turn can influence TNFβ's function.
Other compounds such as ruxolitinib and SP600125 target different components of the cytokine signaling pathways, namely JAK-STAT and JNK pathways, respectively. By altering these signaling pathways, the chemicals can modulate the activity of various cytokines, including TNFβ. These compounds are not exclusive TNFβ inhibitors; instead, they exhibit a broader range of activity across different signaling pathways that intersect with TNFβ's role in the immune response. The modulation of these pathways demonstrates the complex network of interactions that can be targeted to affect the function of a specific cytokine such as TNFβ.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Modulates TNFα production which shares a similar signaling pathway with TNFβ, altering its activity indirectly. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
JAK inhibitor that can affect TNFβ signaling by altering the JAK-STAT pathway, which is downstream of several cytokines, including TNF family members. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
NF-κB inhibitor which can disrupt TNFβ signaling by preventing the transcription of NF-κB dependent genes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Inhibits NF-κB activation and may alter the expression of TNFβ among other cytokines. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $33.00 $64.00 | 11 | |
NF-κB inhibitor that can impede the TNFβ signaling pathway by preventing the transcription of NF-κB dependent genes. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Targets NF-κB and possibly other components of the TNF signaling pathway, including indirect effects on TNFβ. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Inhibits NF-κB activity and could alter the expression and function of TNFβ. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits JNK, which is involved in TNF signaling; this could impact TNFβ signaling indirectly. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $40.00 | 7 | |
NF-κB inhibitor that may affect TNFβ signaling by modulating the expression of genes downstream of TNFβ. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $105.00 $214.00 $6255.00 | 2 | |
Inhibits the release of cytokines including TNFα, and thereby could affect TNFβ signaling indirectly due to pathway crosstalk. | ||||||