TMTC4 Activators
The chemical class of TMTC4 activators includes compounds that enhance the protein's activity through indirect engagement with diverse cellular signaling pathways. Forskolin, by increasing intracellular cAMP levels, can enhance TMTC4 activity through PKA, which may phosphorylate proteins within TMTC4-associated signaling pathways. Ionomycin raises intracellular calcium levels, thereby enhancing TMTC4 activity through the activation of calcium-dependent protein kinases or calcineurin. These interactions suggest that TMTC4's activity is sensitive to changes in cellular second messenger levels, and it is responsive to the consequent activation of downstream kinases.
Autophagy disruptor Chloroquine also suggest TMTC4 involvement in cellular protein management, enhancing its activity by accumulating proteins that trigger compensatory stress responses. Autophagy inducers like Rapamycin and metabolic stressors such as 2-Deoxy-D-glucose can enhance TMTC4 activity through modulation of autophagic flux and energy stress pathways. Moreover, activators like PMA, IBMX, and Curcumin further expand the array of signaling pathways that can enhance TMTC4 activity through PKC activation, sustained cAMP signaling, and modulation of inflammatory responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylyl cyclase, leading to increased intracellular cAMP levels, which in turn can enhance TMTC4 activity via PKA-dependent phosphorylation events within TMTC4-associated pathways. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Calcium ionophore that elevates intracellular calcium levels, potentially enhancing TMTC4 activity through calcium-dependent protein kinases or calcineurin signaling pathways. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Impairs lysosomal acidification and autophagy, which can enhance TMTC4 activity by disrupting autophagic protein turnover and inducing stress responses. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibits mTOR signaling, which can lead to autophagy induction, potentially enhancing TMTC4 activity as part of the cellular response to altered autophagic flux. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
Inhibits glycolysis, potentially enhancing TMTC4 activity by activating AMP-activated protein kinase (AMPK) and subsequent adaptive stress responses. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC), which can enhance TMTC4 activity through PKC-dependent signaling pathways that intersect with TMTC4 functional regulation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Inhibits phosphodiesterases, preventing cAMP degradation and thereby enhancing TMTC4 activity through sustained cAMP-mediated signaling. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Influences multiple signaling pathways including NF-κB, which can enhance TMTC4 activity through modulation of inflammation and cellular stress responses. | ||||||