Tmsb15b1 Activators
Tmsb15b1 Activators, a set of chemical compounds, play a significant role in indirectly enhancing the functional activity of Tmsb15b1 through their influence on various signaling pathways and cellular processes. Forskolin and dbcAMP, by increasing intracellular cAMP levels, activate protein kinase A (PKA), leading to enhanced cytoskeletal organization and cellular migration, processes where Tmsb15b1 is fundamentally involved. Similarly, Phorbol 12-Myristate 13-Acetate (PMA) and Staurosporine influence Tmsb15b1 activity by modulating protein kinase C (PKC) and various protein kinases, respectively, which are integral to cytoskeletal dynamics and cell motility. Additionally, Epigallocatechin Gallate (EGCG) and Genistein, through their kinase inhibitory actions, indirectly potentiate Tmsb15b1's role in cell migration by impacting related signaling pathways. The PI3K inhibitors LY294002 and Wortmannin, by altering AKT signaling, also contribute to the modulation of cytoskeletal organization and cell motility, processes in which Tmsb15b1 is actively involved.
Furthermore, the activity of Tmsb15b1 is influenced by compounds that modulate MAPK signaling, such as U0126 and SB203580, which inhibit MEK and p38 MAPK, respectively. This modulation shifts the signaling dynamics, favoring the pathways associated with Tmsb15b1's role in cell motility and cytoskeletal reorganization. Thapsigargin and Sphingosine-1-Phosphate (S1P) enhance Tmsb15b1's activity by affecting calcium and sphingosine-1-phosphate signaling pathways, crucial for cytoskeletal dynamics and cell migration. These Tmsb15b1 Activators, through their targeted effects on cellular signaling, facilitate the enhancement of Tmsb15b1-mediated functions in cell motility and cytoskeletal organization without directly upregulating its expression or activation.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in modulating the cytoskeleton and cellular motility. The activation of PKC can indirectly enhance Tmsb15b1 function by promoting cytoskeletal reorganization, a process where Tmsb15b1 plays a role. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126, a MEK inhibitor, modifies the MAPK/ERK pathway. This alteration can lead to changes in cellular motility and cytoskeletal dynamics, indirectly enhancing Tmsb15b1 activity, as Tmsb15b1 is implicated in these cellular processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, a PI3K inhibitor, indirectly affects Tmsb15b1 by altering AKT signaling, which is linked to cell motility and cytoskeletal changes. As Tmsb15b1 is associated with these processes, inhibiting PI3K can lead to an indirect enhancement of Tmsb15b1 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, by inhibiting several kinases, can impact signaling pathways that govern cell migration and cytoskeletal dynamics. These pathways are related to Tmsb15b1's function, thus EGCG can indirectly enhance Tmsb15b1 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580, a p38 MAPK inhibitor, can shift cellular responses towards pathways in which Tmsb15b1 is involved, such as cytoskeletal reorganization and cell motility, thereby potentially enhancing Tmsb15b1 activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P, through its actions on sphingosine-1-phosphate receptors, influences cytoskeletal organization and cell migration, processes in which Tmsb15b1 is involved. Thus, S1P can indirectly enhance Tmsb15b1 activity by modulating these pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin elevates intracellular calcium levels, affecting calcium signaling pathways. These pathways intersect with cellular processes like motility and cytoskeletal organization, where Tmsb15b1 plays a role, potentially enhancing Tmsb15b1's activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine, a broad-spectrum protein kinase inhibitor, can influence various signaling pathways related to cell motility and cytoskeletal dynamics. This broad inhibition may indirectly enhance Tmsb15b1's role in these processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor that indirectly affects cell motility and cytoskeletal organization by modulating AKT signaling. Since Tmsb15b1 is involved in these processes, its activity may be indirectly enhanced. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, impacts cellular signaling pathways that control cytoskeletal dynamics and cell migration. This influence can indirectly enhance the activity of Tmsb15b1 in these processes. | ||||||