TMEM9B Inhibitors
Chemical inhibitors of TMEM9B function by interfering with various cellular processes essential for the protein's proper localization, stability, and activity within the cell. Brefeldin A, for example, disrupts the function of the Golgi apparatus, which is integral for processing and trafficking transmembrane proteins like TMEM9B, leading to its dysfunction. Genistein, as a tyrosine kinase inhibitor, can inhibit phosphorylation events that are potentially crucial for the activation or function of TMEM9B. Similarly, Dynasore targets the GTPase dynamin, essential for endocytosis, which can affect the endocytic recycling or degradation of TMEM9B. U18666A and Filipin both disrupt cholesterol homeostasis and lipid raft integrity, respectively, which can alter the membrane environment where TMEM9B resides and is active. GW4869's inhibition of sphingomyelinase alters the sphingomyelin and ceramide levels, further impacting TMEM9B's membrane-associated activities.
Additionally, compounds like Monensin and Ionomycin affect ion gradients and intracellular calcium levels, respectively, which can influence pH and calcium-dependent signaling pathways relevant to TMEM9B function. Gö6976 inhibits protein kinase C, potentially altering the phosphorylation state of TMEM9B or its interacting partners, which is necessary for TMEM9B's activity. Nystatin, binding to membrane sterols, can perturb the membrane's structure and thus affect TMEM9B's conformation and function. Lastly, Tunicamycin inhibits N-linked glycosylation, a modification that could be crucial for the proper folding, stability, or trafficking of TMEM9B, resulting in its functional inhibition.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A inhibits the ADP-ribosylation factor (ARF), a small GTPase involved in vesicle trafficking between the Golgi apparatus and the endoplasmic reticulum. Inhibition of ARF can lead to disruption of Golgi function and protein trafficking, which can inhibit the proper processing and functioning of TMEM9B as it is a transmembrane protein likely to be processed through the Golgi. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can inhibit the phosphorylation of proteins involved in various signaling pathways. Since TMEM9B is a transmembrane protein, it may require phosphorylation for its activation or functioning, thus, inhibition of these kinases can result in functional inhibition of TMEM9B. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore is a GTPase inhibitor that targets dynamin, a protein involved in the scission of clathrin-coated vesicles during endocytosis. By inhibiting dynamin, Dynasore can disrupt endocytic pathways, potentially inhibiting TMEM9B's endocytic recycling or degradation, which is crucial for its function. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $140.00 $500.00 | 2 | |
U18666A is a cholesterol transport inhibitor that can disrupt intracellular cholesterol homeostasis. TMEM9B, being a transmembrane protein, may rely on cholesterol-rich domains for its proper localization or activity, thus, inhibition of cholesterol transport can functionally inhibit TMEM9B. | ||||||
Filipin III | 480-49-9 | sc-205323 sc-205323A | 500 µg 1 mg | $116.00 $145.00 | 26 | |
Filipin is a polyene macrolide that binds to cholesterol, disrupting lipid rafts in cellular membranes. Since TMEM9B is a membrane protein, its activity could be dependent on lipid raft integrity, and disrupting these rafts with Filipin can inhibit the function of TMEM9B. | ||||||
GW4869 | 6823-69-4 | sc-218578 sc-218578A | 5 mg 25 mg | $199.00 $599.00 | 24 | |
GW4869 is an inhibitor of sphingomyelinase, which can alter the levels of sphingomyelin and ceramide in membranes. As TMEM9B is a membrane protein, changes in membrane composition can inhibit its function by affecting its localization or the lipid microenvironment necessary for its activity. | ||||||
6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-Dione | 118876-58-7 | sc-478080 | 5 mg | $70.00 | 1 | |
NBQX is an AMPA receptor antagonist that can inhibit excitatory neurotransmission. Though not directly linked to TMEM9B, neurotransmitter imbalances can affect cellular signaling pathways that might intersect with TMEM9B's function, leading to its inhibition. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is a carboxylic ionophore that alters ion gradients across membranes. This can affect the pH and ion homeostasis in organelles like the Golgi, which could inhibit the proper maturation and function of a transmembrane protein like TMEM9B. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that elevates intracellular calcium levels. Elevated calcium levels can affect several signaling pathways and membrane trafficking processes that are necessary for the function of transmembrane proteins like TMEM9B, thus inhibiting its function. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $223.00 | 8 | |
Gö6976 is a protein kinase C inhibitor. Inhibition of protein kinase C can alter the phosphorylation state of several proteins, potentially including TMEM9B or proteins that interact with it, thereby inhibiting its function. | ||||||