TMEM80 Inhibitors
Chemical inhibitors of TMEM80 can modulate the protein's function through various mechanisms, all of which revolve around the manipulation of calcium levels within the cell. Tetrandrine, for example, serves as a calcium channel blocker, preventing calcium influx and possibly leading to a disruption in the endoplasmic reticulum (ER) calcium homeostasis, a vital environment for TMEM80 functionality. Similarly, Ruthenium Red and SKF-96365 inhibit calcium channels and calcium entry, respectively, with the former also interfering with mitochondrial calcium uptake. These actions can impede TMEM80's role in regulating intracellular calcium. The function of TMEM80 would also be affected by 2-APB, known for its inhibition of IP3 receptors and store-operated calcium channels, which are crucial for TMEM80's operation in calcium signaling. Thapsigargin presents another approach by inhibiting the SERCA pump, leading to ER calcium store depletion, thus perturbing the cellular calcium balance critical for TMEM80's regulatory activities.
Continuing with the array of inhibitors, Ryanodine and TMB-8 exert their effects by binding to ryanodine receptors and antagonizing intracellular calcium release, respectively, both of which are essential for TMEM80's presumed role in calcium regulation. BAPTA, with its calcium chelating properties, binds free calcium ions, diminishing the intracellular calcium concentration, which is fundamental for TMEM80's function. Xestospongin C targets the IP3 receptor, preventing calcium release from the ER and thereby impacting TMEM80's ability to manage calcium levels within the cell. Carboxyeosin's inhibition of the Na+/Ca2+ exchanger would likely affect TMEM80's role by altering calcium exchange across the cell membrane. Lastly, calcium channel blockers like Nifedipine and Verapamil, by impeding the influx of calcium ions, would disrupt the regulated calcium levels within cells, which TMEM80 relies upon for its proper function in maintaining intracellular calcium homeostasis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tetrandrine | 518-34-3 | sc-201492 sc-201492A | 100 mg 250 mg | $55.00 $98.00 | 9 | |
Tetrandrine is a calcium channel blocker that can inhibit calcium influx. Since TMEM80 is implicated in calcium homeostasis within the endoplasmic reticulum (ER), tetrandrine's effect on calcium channels can inhibit the proper functioning of TMEM80 by disrupting ER calcium levels. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Ruthenium Red inhibits calcium uptake by mitochondria and can also inhibit calcium channels. TMEM80's function is closely related to calcium homeostasis, and the disruption of calcium channels can inhibit TMEM80's activity in calcium regulation. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SKF-96365 inhibits receptor-mediated calcium entry as well as store-operated calcium entry (SOCE). TMEM80, involved in intracellular calcium regulation, would be functionally inhibited by the disruption of SOCE, impacting ER calcium levels and homeostasis. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB is known to inhibit IP3 receptors and store-operated calcium channels. TMEM80, which may be involved in ER-mitochondria calcium transfer, would be inhibited by the disruption of IP3-mediated calcium release, affecting its function within the cell. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor, which leads to depletion of ER calcium stores. By inhibiting the reuptake of calcium into the ER, thapsigargin would disrupt the calcium-dependent functions of TMEM80 by altering intracellular calcium homeostasis. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $219.00 $765.00 | 19 | |
Ryanodine selectively binds to ryanodine receptors and modifies their function. It can block the calcium release from the ER, thus inhibiting the calcium-dependent regulatory functions of TMEM80, which require precise calcium signaling for proper functioning. | ||||||
BAPTA, Free Acid | 85233-19-8 | sc-201508 sc-201508A | 100 mg 500 mg | $67.00 $262.00 | 10 | |
BAPTA is a calcium chelator that can bind free calcium ions, effectively reducing the intracellular calcium concentration. TMEM80, which is functionally involved in calcium-dependent processes, would be inhibited due to the lack of available calcium. | ||||||
Xestospongin C | 88903-69-9 | sc-201505 | 50 µg | $500.00 | 14 | |
Xestospongin C is an inhibitor of the IP3 receptor. By preventing the release of calcium from the ER, it would inhibit TMEM80's ability to regulate intracellular calcium levels, as TMEM80 is thought to be involved in ER-mitochondrial calcium signaling. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is a calcium channel blocker that inhibits the influx of calcium ions into cells. This inhibition can disrupt the ER calcium levels, which are critical for the function of TMEM80 in regulating calcium homeostasis and signaling. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is another calcium channel blocker that inhibits L-type calcium channels. By blocking these channels, verapamil would disrupt the calcium balance within the cell and consequently inhibit the function of TMEM80, which is dependent on regulated calcium levels. | ||||||