TMEM46 Inhibitors
Protein Shisa-2 Homolog (TMEM46) inhibitors target the FGF and WNT signaling pathways, indirectly influencing TMEM46's function in the maturation of presomitic mesoderm cells. FGF receptor inhibitors like PD173074 and SU 5402 are included as they could indirectly affect TMEM46's role in modulating FGF signaling. WNT signaling inhibitors such as IWP-2, XAV939, LGK-974, and KY02111 are significant due to their potential impact on the pathways where TMEM46 is involved. BML-275, by inhibiting BMP signaling, and Y-27632, free base, a ROCK inhibitor, are included for their potential influence on cellular pathways related to TMEM46's function in mesodermal development.
U0126, a MEK inhibitor, could indirectly affect FGF signaling pathways involving TMEM46. SM04554, a modulator of the WNT pathway, is relevant for its potential to influence TMEM46-related signaling. Pirfenidone and SB 431542 target TGF-β signaling, which can be interconnected with mesoderm development processes involving TMEM46. In summary, the strategy for targeting TMEM46 involves modulating key signaling pathways such as FGF and WNT, which are critical in the maturation of presomitic mesoderm cells where TMEM46 plays a role.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
A selective FGF receptor inhibitor, could indirectly affect TMEM46's role in FGF signaling modulation. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
Inhibits WNT production, potentially impacting TMEM46's function in WNT signaling. | ||||||
SU 5402 | 215543-92-3 | sc-204308 sc-204308A | 1 mg 5 mg | $62.00 $96.00 | 36 | |
Another FGF receptor inhibitor, might influence FGF pathways regulated by TMEM46. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
Targets the WNT/β-catenin pathway, potentially affecting pathways involving TMEM46. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $352.00 $1270.00 | 2 | |
A WNT signaling inhibitor, could impact TMEM46-related pathways. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $94.00 $348.00 | 69 | |
Inhibits BMP (Bone Morphogenetic Proteins) signaling, potentially influencing pathways interconnected with TMEM46's role. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A ROCK inhibitor, might affect cellular pathways related to TMEM46's function. | ||||||
Pirfenidone | 53179-13-8 | sc-203663 sc-203663A | 10 mg 50 mg | $100.00 $408.00 | 6 | |
Inhibits TGF-β signaling, potentially affecting mesoderm development processes involving TMEM46. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
An inhibitor of the TGF-β receptor, might impact signaling pathways related to TMEM46. | ||||||