TMEM249 Inhibitors
Chemical inhibitors of TMEM249 can modulate the activity of this protein through various molecular signaling pathways by selectively blocking the activity of enzymes that are crucial for the functioning of TMEM249. Bisindolylmaleimide I, known for its ability to inhibit protein kinase C (PKC), can reduce the phosphorylation of TMEM249, assuming it to be a substrate of PKC. Similarly, Wortmannin and LY294002, both inhibitors of phosphoinositide 3-kinases (PI3K), can inhibit TMEM249 by disrupting the PI3K/AKT pathway, which may be integral to TMEM249's regulation. Moreover, SB203580 and PD98059 target different kinases within the MAP kinase pathway; SB203580 inhibits p38 MAP kinase while PD98059 inhibits MEK1/2, which is upstream of ERK. If TMEM249 is regulated through the p38 MAPK or MEK/ERK pathway, these inhibitors would impede the pathway's influence on TMEM249.
Further, SP600125, which specifically inhibits c-Jun N-terminal kinase (JNK), can inhibit TMEM249 if JNK signaling is vital for its activity. U0126, another MEK inhibitor, can suppress TMEM249 by blocking the MEK/ERK pathway. PP2, targeting Src family tyrosine kinases, can inhibit TMEM249 if Src family kinases are required for TMEM249's phosphorylation and subsequent activity. The Rho-associated protein kinase (ROCK) inhibitor, Y-27632, can also inhibit TMEM249 if ROCK activity is necessary for TMEM249-mediated processes. Gefitinib, an epidermal growth factor receptor (EGFR) inhibitor, can inhibit TMEM249 by impeding EGFR signaling. Lastly, Rapamycin, an mTOR inhibitor, can suppress TMEM249 activity if TMEM249 is involved in mTOR-regulated pathways, while Palbociclib, an inhibitor of cyclin-dependent kinases CDK4 and CDK6, can inhibit TMEM249 if it is regulated by these kinases during the cell cycle.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
This compound specifically inhibits protein kinase C (PKC), which is a family of protein kinases involved in controlling the function of other proteins. By inhibiting PKC, Bisindolylmaleimide I could reduce the phosphorylation of TMEM249, presuming TMEM249 is a substrate of PKC, leading to its functional inhibition. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K). If TMEM249 is regulated by the PI3K/AKT pathway, the inhibition of PI3K by Wortmannin would disrupt downstream signaling that may be required for TMEM249 function, thereby inhibiting TMEM249. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another inhibitor of PI3K. Similar to Wortmannin, it would inhibit TMEM249 function by blocking the PI3K/AKT pathway, assuming that this pathway plays a role in the regulation or activation of TMEM249. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
This compound is an inhibitor of p38 MAP kinase. If TMEM249 function is contingent upon signaling through the p38 MAPK pathway, SB203580 would inhibit TMEM249 by blocking this specific kinase activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 selectively inhibits Mitogen-Activated Protein Kinase Kinase (MEK), which is upstream of the ERK pathway. If TMEM249 is regulated by the MEK/ERK pathway, inhibition of MEK by PD98059 would block the pathway's influence on TMEM249, leading to its inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). If TMEM249 is part of cellular processes that are regulated by JNK signaling, inhibition of JNK by SP600125 would result in the functional inhibition of TMEM249. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of both MEK1 and MEK2. If TMEM249 is dependent on MEK/ERK pathway for its function, U0126 would inhibit this pathway, thereby inhibiting TMEM249. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases. If TMEM249 requires phosphorylation by Src family kinases for its activity, PP2 would inhibit these kinases, leading to the inhibition of TMEM249. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is an inhibitor of Rho-associated protein kinase (ROCK). If TMEM249 operates within signaling pathways that require ROCK activity, then Y-27632 inhibition of ROCK would lead to the functional inhibition of TMEM249. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib is an epidermal growth factor receptor (EGFR) inhibitor. If TMEM249's function is influenced by EGFR signaling, then Gefitinib would functionally inhibit TMEM249 by blocking this pathway. | ||||||