TMEM231 Inhibitors
Chemicals classified as TMEM231 Inhibitors are compounds that can indirectly affect the functional pathways of the TMEM231 protein. Since TMEM231 is implicated in the structure and function of primary cilia and the Shh signaling pathway, compounds that disrupt these functions can serve as indirect inhibitors. Cyclopamine, vismodegib, GANT61, jervine, SANT1, SANT2, and itraconazole are examples of molecules that target the Shh pathway at different points; cyclopamine and jervine by directly interfering with components like Smoothened or the Gli transcription factors, while vismodegib, SANT1, SANT2, and itraconazole act as antagonists to Smoothened, thereby hindering the pathway's activation and possibly affecting the functional contributions of TMEM231.
On the other hand, compounds like forskolin, U18666A, mebendazole, ciliobrevin A, and ciliobrevin D affect the ciliary structure and function. Forskolin, by increasing cAMP levels, can modulate ciliary beat frequency and function, while U18666A can alter the composition of the ciliary membrane. Mebendazole compromises microtubule stability, thus potentially affecting ciliogenesis and ciliary maintenance where TMEM231 is involved. Ciliobrevin A and D inhibit ciliary trafficking and hence can influence TMEM231's role in ciliary assembly and function.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Hedgehog signaling pathway inhibitor; can disrupt Shh signaling, potentially affecting TMEM231's function in this pathway. | ||||||
Vismodegib | 879085-55-9 | sc-396759 sc-396759A | 10 mg 25 mg | $80.00 $96.00 | 1 | |
Smoothened antagonist; can block downstream effects of the Shh pathway, potentially impacting TMEM231's role. | ||||||
GANT61 | 500579-04-4 | sc-202630 sc-202630A sc-202630B | 1 mg 5 mg 10 mg | $63.00 $128.00 $200.00 | 6 | |
Gli antagonist; can inhibit the transcription of hedgehog target genes, potentially affecting TMEM231's role in cilia. | ||||||
Jervine | 469-59-0 | sc-200934 sc-200934A | 1 mg 5 mg | $66.00 $240.00 | 1 | |
Hedgehog pathway inhibitor; can alter hedgehog signaling, potentially affecting TMEM231's functional roles. | ||||||
SANT-1 | 304909-07-7 | sc-203253 | 5 mg | $132.00 | 5 | |
Smoothened antagonist; can disrupt Shh pathway signaling, potentially impacting TMEM231-related processes. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Adenylyl cyclase activator; can increase cAMP levels, potentially affecting TMEM231's role in cilia function. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $140.00 $500.00 | 2 | |
Cholesterol transport inhibitor; can disrupt ciliary membrane composition, potentially affecting TMEM231 localization and function. | ||||||
Mebendazole | 31431-39-7 | sc-204798 sc-204798A | 5 g 25 g | $45.00 $87.00 | 2 | |
Microtubule destabilizer; can affect ciliary structure and function, potentially impacting TMEM231's role in ciliogenesis. | ||||||
HPI-4 | 302803-72-1 | sc-358720 sc-358720A | 5 mg 25 mg | $133.00 $530.00 | ||
Dynein ATPase inhibitor; can disrupt ciliary trafficking, potentially affecting TMEM231's role in cilia. | ||||||
Ciliobrevin D | 1370554-01-0 | sc-507482 | 10 mg | $413.00 | ||
Hedgehog signaling pathway inhibitor; can disrupt primary cilia formation, potentially influencing TMEM231 if it plays a role in ciliogenesis. | ||||||