TMEM213 Inhibitors
TMEM213 inhibitors are a class of chemicals that can directly or indirectly inhibit the function of the TMEM213 protein. TMEM213, also known as Transmembrane Protein 213, is a transmembrane protein whose specific function is not well characterized. However, it is known to be involved in cellular processes that may include protein trafficking, ion homeostasis, membrane integrity, cell signaling, calcium homeostasis, protein glycosylation, protein synthesis, mitochondrial function, and lysosomal function. The inhibitors listed above can target various cellular processes and pathways that may be regulated by TMEM213, leading to indirect inhibition of its function. For example, Brefeldin A disrupts intracellular protein trafficking by targeting the Golgi apparatus, which can indirectly affect TMEM213 function. Monensin A disrupts ion homeostasis by interfering with ion transport across cellular membranes, influencing TMEM213-mediated processes. Nystatin, Streptomyces noursei disrupts membrane integrity by targeting ergosterol, leading to membrane permeabilization and disruption of cellular processes that may involve TMEM213. Other inhibitors, such as Wortmannin, Bafilomycin A1, and Thapsigargin, target specific signaling pathways or cellular processes, such as the phosphoinositide 3-kinase (PI3K) pathway, vacuolar-type H+-ATPase (V-ATPase) proton pump, and sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) pump, respectively. These inhibitors can disrupt downstream signaling pathways or cellular processes that may be regulated by TMEM213.
Furthermore, inhibitors like Tunicamycin, Cycloheximide, and 2,4-Dinitrophenol, wetted interfere with protein glycosylation, protein synthesis, and mitochondrial function, respectively, which can indirectly affect TMEM213-mediated processes. N-Ethylmaleimide modifies cysteine residues, disrupting protein structure and function, and indirectly impacting TMEM213 function. Chloroquine interferes with lysosomal function, which can indirectly affect TMEM213-mediated processes. Lastly, Geldanamycin targets heat shock protein 90 (HSP90), leading to protein folding disruption and impact on TMEM213 function. In summary, TMEM213 inhibitors encompass a diverse group of chemicals that can directly or indirectly inhibit the function of TMEM213 by targeting various cellular processes and pathways. These inhibitors provide valuable tools for studying the role of TMEM213 in cellular physiology and may have implications in understanding its involvement in disease processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A is a fungal metabolite that can inhibit TMEM213 by disrupting intracellular protein trafficking. It specifically targets the Golgi apparatus, leading to the inhibition of protein transport and secretion, which can indirectly affect the function of TMEM213. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin A is an ionophore antibiotic that can inhibit TMEM213 by disrupting intracellular ion homeostasis. It can specifically disrupt the transport of sodium and potassium ions across cellular membranes, which can indirectly affect the function of TMEM213. | ||||||
Nystatin | 1400-61-9 | sc-212431 sc-212431A sc-212431B sc-212431C | 5 MU 25 MU 250 MU 5000 MU | $51.00 $129.00 $251.00 $3570.00 | 7 | |
Nystatin, Streptomyces noursei is an antifungal agent that can inhibit TMEM213 by disrupting membrane integrity. It specifically targets ergosterol, a component of fungal cell membranes, leading to membrane permeabilization and disruption of cellular processes, which can indirectly affect the function of TMEM213. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a fungal metabolite that can inhibit TMEM213 by targeting phosphoinositide 3-kinase (PI3K) signaling pathway. It specifically inhibits PI3K, an enzyme involved in cell signaling, leading to the disruption of downstream signaling pathways that may be involved in the regulation of TMEM213. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is a macrolide antibiotic that can inhibit TMEM213 by targeting the vacuolar-type H+-ATPase (V-ATPase) proton pump. It specifically inhibits the proton pump activity, leading to the disruption of intracellular pH homeostasis and cellular processes that may be regulated by TMEM213. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a plant-derived compound that can inhibit TMEM213 by targeting the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) pump. It specifically inhibits the SERCA pump, leading to the disruption of calcium homeostasis and cellular processes that may be regulated by TMEM213. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin is an antibiotic that can inhibit TMEM213 by interfering with protein glycosylation. It specifically inhibits the enzyme UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, leading to the disruption of protein glycosylation and cellular processes that may be regulated by TMEM213. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide is a protein synthesis inhibitor that can inhibit TMEM213 by blocking ribosome function. It specifically inhibits the translocation step of protein synthesis, leading to the disruption of protein production and cellular processes that may be regulated by TMEM213. | ||||||
2,4-Dinitrophenol, wetted | 51-28-5 | sc-238345 | 250 mg | $59.00 | 2 | |
2,4-Dinitrophenol, wetted is an uncoupler of oxidative phosphorylation that can inhibit TMEM213 by disrupting mitochondrial function. It specifically disrupts the proton gradient across the inner mitochondrial membrane, leading to the uncoupling of ATP synthesis and cellular processes that may be regulated by TMEM213. | ||||||
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $69.00 $214.00 $796.00 $1918.00 | 19 | |
N-Ethylmaleimide (NEM) is a thiol-reactive compound that can inhibit TMEM213 by modifying cysteine residues. It specifically reacts with sulfhydryl groups, leading to the disruption of protein structure and function, which can indirectly affect the function of TMEM213. | ||||||