TMEM170 Activators
Forskolin stands out as it directly stimulates adenylate cyclase, causing an increase in cAMP levels, which can lead to the activation of PKA; a kinase likely to phosphorylate downstream proteins associated with TMEM170. IBMX complements this by inhibiting the breakdown of cAMP, amplifying the signaling effects that might affect TMEM170. PMA activates PKC, initiating phosphorylation events, while kinase inhibitors like Staurosporine and Gö 6983 adjust the phosphorylation state of proteins within TMEM170-related pathways.
Calcium signaling modifiers such as U73122, W-7 Hydrochloride, and KN-93 influence phospholipase C, calmodulin, and Ca2+/calmodulin-dependent protein kinases, respectively, hinting at their potential to intersect with TMEM170-mediated pathways due to the role of calcium in cellular signaling. Genistein inhibits tyrosine kinases, which could lead to alterations in TMEM170-associated pathways. Similarly, LY294002 and PD98059 target the PI3K/Akt and MAPK/ERK pathways, central conduits for numerous cellular responses, potentially affecting TMEM170.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Activates AMP-activated protein kinase (AMPK), potentially enhancing TMEM188 activity through improved cellular energy homeostasis. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
Direct AMPK activator, potentially modulating TMEM188 activity via pathways related to metabolic stress. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $82.00 $179.00 | 28 | |
Activates PPARδ, potentially influencing TMEM188 activity through lipid metabolism and energy regulation. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
Mimics cyclic AMP, potentially influencing TMEM188 activity through cAMP-dependent signaling pathways. | ||||||
SKL2001 | 909089-13-0 | sc-507410 | 10 mg | $123.00 | ||
Modulates Wnt/β-catenin signaling, potentially affecting TMEM188 activity related to cell fate and proliferation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Inhibits histone deacetylases, potentially affecting TMEM188 activity through transcriptional regulation. | ||||||
MHY1485 | 326914-06-1 | sc-507522 | 10 mg | $140.00 | ||
Activates mTOR signaling pathway, potentially enhancing TMEM188 function related to protein synthesis and cell growth. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
Reduces endoplasmic reticulum stress, potentially influencing TMEM188 activity by improving protein folding and function. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Increases intracellular calcium levels, potentially modulating TMEM188 activity via calcium-signaling pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Activates NRF2, potentially enhancing TMEM188 function related to oxidative stress defense. | ||||||