TMEM160 Activators
TMEM160 Activators are a diverse group of chemical compounds that indirectly enhance the functional activity of TMEM160 through various signaling pathways, adapting to the protein's role in cellular stress responses, metabolic processes, and signal transduction. Resveratrol and Nicotinamide Riboside, by influencing the SIRT1 signaling pathway and NAD+ metabolism respectively, facilitate TMEM160 activation in response to cellular stress and energy demands. Similarly, AMPK activators like AICAR and Metformin indirectly stimulate TMEM160 by modulating energy metabolism pathways, which TMEM160 is intricately connected to. In the realm of ionic regulation, Calcium Ionophore A23187 heightens intracellular calcium levels, triggering calcium-dependent signaling cascades that in turn augment TMEM160's activity, reflecting its sensitivity to ionic changes within the cell.
Further extending the repertoire of TMEM160 activators, Forskolin, Curcumin, and Lithium Chloride modulate various key signaling pathways, including cAMP/PKA, NF-kB, and Wnt/GSK-3 respectively. These pathways, central to cellular communication and response mechanisms, indirectly prime TMEM160 for enhanced functional activity. In the context of cellular growth and stress response, Rapamycin and 17-AAG, by targeting mTOR and HSP90, lead to an indirect activation of TMEM160, as the protein plays a role in compensatory mechanisms associated with cell growth and protein homeostasis. PD98059 and Sodium Butyrate, impacting the MAPK/ERK pathway and chromatin remodeling, respectively, further illustrate the complex network of pathways influencing TMEM160 activity. Collectively, these chemical activators, through targeted effects on cellular signaling, metabolic regulation, and stress responses, facilitate the enhancement of TMEM160's functions, intricately tying its activity to a broad spectrum of cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol found in grapes, influences the SIRT1 signaling pathway. TMEM160, being associated with cellular stress responses, is indirectly activated through SIRT1's role in cellular protection mechanisms. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR, an AMPK activator, enhances cellular energy metabolism. TMEM160, involved in metabolic processes, is indirectly activated via AMPK-mediated signaling pathways that adjust cellular energy balance. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin, primarily used in diabetes management, activates AMPK signaling. This leads to an indirect activation of TMEM160 due to its involvement in metabolic pathways influenced by AMPK. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 elevates intracellular calcium levels, influencing calcium-dependent signaling pathways. TMEM160, responsive to changes in cellular ionic balance, is indirectly activated by these calcium-mediated signaling alterations. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, through cAMP elevation, activates PKA. This indirect activation pathway enhances TMEM160 activity by modulating signaling cascades in which TMEM160 plays a regulatory role. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin modulates NF-kB signaling, a pathway relevant in inflammation and stress responses. TMEM160, associated with cellular response mechanisms, is indirectly activated through NF-kB pathway modulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a key regulator of cell growth and proliferation. TMEM160, involved in pathways related to cell growth, is indirectly activated as mTOR inhibition triggers compensatory mechanisms that include TMEM160 activation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059, a MEK inhibitor, alters the MAPK/ERK pathway. TMEM160, involved in cell signaling processes, is indirectly activated as a result of these pathway modifications. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3, influencing Wnt signaling. TMEM160, having roles in cellular signaling processes, is indirectly activated through the modulation of Wnt/GSK-3 signaling pathways. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
Nicotinamide riboside, a NAD+ precursor, influences SIRT1 and PARP pathways. TMEM160, involved in cellular stress responses, is indirectly activated by these pathways' modulation. | ||||||