TMEM160 Inhibitors
Chemical inhibitors of TMEM160 can interfere with the protein's function through various molecular mechanisms, each related to the inhibition of specific enzymes and signaling pathways within the cell. Genistein and Staurosporine, for instance, target the activity of tyrosine kinases, which are enzymes that catalyze the phosphorylation of proteins on tyrosine residues. This post-translational modification is pivotal for the regulation of protein activity, interaction with other cellular components, and the overall cellular signaling landscape. As such, the presence of Genistein and Staurosporine can reduce the phosphorylation of proteins that are within the functional pathway of TMEM160 or directly involved in its activity, resulting in a diminishment of TMEM160's functional output. Similarly, the Src family kinases, which are also a subset of tyrosine kinases, are targeted by PP2, leading to a similar outcome where the regulation or activity of TMEM160 is altered.
In tandem with these, LY294002 and Wortmannin exert their effects by inhibiting phosphoinositide 3-kinases (PI3K), which play a crucial role in cell growth, proliferation, and survival, as well as in membrane trafficking processes that can affect protein localization and stability. By hampering PI3K activity, these inhibitors can alter the membrane dynamics and cellular context in which TMEM160 operates, potentially leading to its functional inhibition. Furthermore, the MAPK/ERK and p38 MAPK signaling pathways are targeted by PD98059, SB203580, and U0126, which can disrupt the phosphorylation and activation of proteins that may influence TMEM160's function. In addition, SP600125 inhibits c-Jun N-terminal kinase (JNK), which could modify the activity of transcription factors and alter the cellular levels or activity of TMEM160. NF449, by inhibiting the Gs-alpha subunit of G proteins, can disrupt G protein-coupled receptor signaling pathways that may modulate the function of TMEM160. Lastly, calcium signaling, which is vital for a myriad of cellular processes, is targeted by both BAPTA-AM, a chelator that sequesters intracellular calcium ions, and Thapsigargin, which disrupts calcium homeostasis by inhibiting the SERCA pump. These alterations in calcium dynamics can affect calcium-dependent regulatory mechanisms that influence the function of TMEM160.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, an isoflavone found in soy products, has been shown to inhibit tyrosine kinases. TMEM160's function may depend on phosphorylation events mediated by these enzymes. By inhibiting tyrosine kinases, Genistein can reduce the phosphorylation of proteins within the same pathway as TMEM160, leading to a functional inhibition of TMEM160. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. As TMEM160 is likely to interact with kinases for its function or stability, Staurosporine can inhibit these kinases, thereby inhibiting the activity of TMEM160. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a phosphoinositide 3-kinases (PI3K) inhibitor. Since PI3K signaling is often involved in the regulation of membrane proteins, inhibition of PI3K can lead to altered membrane dynamics, potentially inhibiting the function of TMEM160 by changing its localization or stability. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another inhibitor of PI3K. It can inhibit the PI3K-dependent pathways that may regulate the trafficking and function of TMEM160, thus functionally inhibiting TMEM160. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of mitogen-activated protein kinase kinase (MEK). MEK is part of the MAPK/ERK pathway, which could regulate the activity or localization of TMEM160. Inhibition of MEK may, therefore, functionally inhibit TMEM160 by preventing its proper functioning within the cell. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. By inhibiting p38 MAPK, the chemical may disrupt downstream signaling pathways that are involved in the regulation of TMEM160 activity, leading to its functional inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). Inhibiting JNK can alter the activity of transcription factors and other proteins that regulate TMEM160, leading to its functional inhibition. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family tyrosine kinases. Src kinases can regulate multiple cellular processes including those that may involve TMEM160. By inhibiting Src kinases, PP2 can lead to functional inhibition of TMEM160 by altering its regulation or activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, part of the MAPK/ERK pathway. Inhibition of this pathway can alter the phosphorylation state and activity of proteins associated with TMEM160, thereby inhibiting TMEM160 function. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $199.00 $460.00 $1479.00 | 1 | |
NF449 is a potent and selective inhibitor of the Gs-alpha subunit of G proteins. Inhibition of Gs-alpha can disrupt G protein-coupled receptor signaling pathways that may indirectly influence the function of TMEM160, leading to its functional inhibition. | ||||||