TMEM120B Inhibitors
Chemical inhibitors of TMEM120B can be understood by examining their interactions with cellular pathways linked to the functions of this protein. Benzamil, a sodium channel inhibitor, can disrupt the sodium balance within cells, which is critical for the function of ion channel-associated proteins like TMEM120B. By inhibiting sodium channels, Benzamil can reduce the activity of TMEM120B if it is associated with or regulated by sodium ion flux. Ruthenium Red, which interacts with calcium channels, can inhibit TMEM120B by altering intracellular calcium levels, a key element in the signaling pathways where TMEM120B may play a role. Similarly, 2-APB, known for blocking certain calcium channels, can inhibit TMEM120B by disrupting the calcium homeostasis within cells, which could be vital for TMEM120B's function.
The inhibitor SKF-96365 can prevent receptor-mediated calcium entry, which can alter the function of TMEM120B if it is involved in calcium signaling. GsMTx4, which inhibits mechanosensitive ion channels, can inhibit TMEM120B by interfering with its potential role in mechanosensation. The same mechanism of inhibition can apply to the Gadolinium ion, which can block these channels and subsequently inhibit the function of TMEM120B. Mibefradil and TTA-Q6, both of which inhibit different types of calcium channels, can alter the cellular calcium dynamics, leading to the inhibition of TMEM120B. This is because the correct function of calcium channels can be essential for TMEM120B's activity within cellular signaling pathways. ML204, a TRPC4 channel inhibitor, can also inhibit TMEM120B by preventing the proper function of these channels if TMEM120B is functionally linked to them. Nifedipine's blockade of L-type calcium channels can similarly inhibit TMEM120B by disrupting calcium signaling. Lastly, A-967079 and Pyr3, which selectively inhibit TRPA1 and TRPC3 channels respectively, can inhibit TMEM120B by affecting the function of these mechanosensitive ion channels, which TMEM120B may be associated with or regulated by.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benzamil•HCl | 161804-20-2 | sc-201070 | 50 mg | $195.00 | 1 | |
Inhibits sodium channels which TMEM120B has been suggested to associate with, leading to inhibition of TMEM120B activity. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Interacts with and inhibits various calcium channels, potentially inhibiting TMEM120B which is implicated in calcium signaling. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
Blocks certain calcium channels and could inhibit TMEM120B activity by disrupting calcium homeostasis within the cell. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
Inhibitor of receptor-mediated calcium entry, which may inhibit TMEM120B's potential role in calcium signaling pathways. | ||||||
Gadolinium | 7440-54-2 | sc-250038 | 10 g | $87.00 | ||
Known to block mechanosensitive channels, which could inhibit TMEM120B if it functions as a mechanosensitive ion channel. | ||||||
Mibefradil dihydrochloride | 116666-63-8 | sc-204083 sc-204083A | 10 mg 50 mg | $209.00 $848.00 | 4 | |
Inhibits certain types of calcium channels, potentially inhibiting the calcium-related functions of TMEM120B within cells. | ||||||
4-Methyl-2-(1-piperidinyl)-quinoline | 5465-86-1 | sc-483337 | 25 mg | $430.00 | ||
Inhibits TRPC4 channels, potentially inhibiting TMEM120B function if there is an interaction with this type of channel. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Blocks L-type calcium channels, which could inhibit TMEM120B by altering calcium signaling pathways it may be involved in. | ||||||
A-967079 | 1170613-55-4 | sc-363348 sc-363348A sc-363348B | 5 mg 25 mg 100 mg | $86.00 $365.00 $924.00 | 5 | |
Selectively inhibits TRPA1 channels, potentially inhibiting TMEM120B by affecting associated mechanosensitive ion channel functions. | ||||||
Pyr3 | 1160514-60-2 | sc-301624 sc-301624A sc-301624B | 5 mg 10 mg 25 mg | $148.00 $255.00 $510.00 | ||
Blocks TRPC3 channels, which could indirectly inhibit TMEM120B if it has functional interactions with these channels. | ||||||