Pyr3 (CAS 1160514-60-2)
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Pyr3 is a pyrazole compound that potently and selectively antagonizes TRPC3. Pyr3 inhibits TRPC3 by binding to the extracellular side of the receptor, resulting in suppression of B cell activation and cardiac hypertrophy. Members of the canonical transient receptor potential (TRPC) channel family are ion channels which conduct Ca+2 and are activated by membrane receptor-mediated stimulation of phospholipase C (PLC) activity. However, TRPC3 and other family members are also activated by membrane-independent diacylglycerol (DAG). BTP1 and BTP2 are pyrazoles that block TRPC channels, but they are not specific for TRPC subtypes. This channel is implicated in various processes, including B cell receptor (BCR)-mediated Ca+2 oscillations, activation of nuclear factor of activated T cells (NFAT), and promotion of cardiac hypertrophy.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pyr3, 5 mg | sc-301624 | 5 mg | $148.00 | |||
Pyr3, 10 mg | sc-301624A | 10 mg | $255.00 | |||
Pyr3, 25 mg | sc-301624B | 25 mg | $510.00 |