Molecular structure of A-967079, CAS Number: 1170613-55-4
A-967079 (CAS 1170613-55-4)
See product citations (5)
Alternate Names:
(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-penten-3-one oxime
Application:
A-967079 is antagonist of Transient Receptor Potential Anykrin 1 (TRPA1)
CAS Number:
1170613-55-4
Molecular Weight:
207.24
Molecular Formula:
C12H14FNO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A-967079 is a potent and selective antagonist of Transient Receptor Potential Anykrin 1 (TRPA1). Structurally related to AP-18. A-967079 displays 1000-fold selectivity for TRPA1 over other TRP channels, and is >150-fold selective over 75 other ion channels, enzymes and G-protein-coupled receptors. Exhibits analgesic effects in a rat osteoarthritic pain model.
A-967079 (CAS 1170613-55-4) References
- TRPV1 antagonist BCTC inhibits pH 6.0-induced pain in human skin. | Heber, S., et al. 2020. Pain. 161: 1532-1541. PMID: 32107360
- Analysis of TRPA1 antagonist, A-967079, in plasma using high-performance liquid chromatography tandem mass-spectrometry. | Gyamfi, OA., et al. 2020. J Pharm Anal. 10: 157-163. PMID: 32373387
- Functional expression of the transient receptor potential ankyrin type 1 channel in pancreatic adenocarcinoma cells. | Cojocaru, F., et al. 2021. Sci Rep. 11: 2018. PMID: 33479347
- Interleukin 1 beta-induced calcium signaling via TRPA1 channels promotes mitogen-activated protein kinase-dependent mesangial cell proliferation. | Soni, H., et al. 2021. FASEB J. 35: e21729. PMID: 34143493
- Oxaliplatin Depolarizes the IB4- Dorsal Root Ganglion Neurons to Drive the Development of Neuropathic Pain Through TRPM8 in Mice. | Wu, B., et al. 2021. Front Mol Neurosci. 14: 690858. PMID: 34149356
- Transient Receptor Potential Ankyrin-1 (TRPA1) Block Protects against Loss of White Matter Function during Ischaemia in the Mouse Optic Nerve. | Lajoso, W., et al. 2021. Pharmaceuticals (Basel). 14: PMID: 34577609
- Slack Potassium Channels Modulate TRPA1-Mediated Nociception in Sensory Neurons. | Zhou, F., et al. 2022. Cells. 11: PMID: 35626730
- Structural Modeling of TRPA1 Ion Channel-Determination of the Binding Site for Antagonists. | Gawalska, A., et al. 2022. Molecules. 27: PMID: 35630553
- An LPAR 5 -antagonist that reduces nociception and increases pruriception. | Langedijk, J., et al. 2022. Front Pain Res (Lausanne). 3: 963174. PMID: 35959236
- Reevaluation of Piezo1 as a gut RNA sensor. | Nickolls, AR., et al. 2022. Elife. 11: PMID: 36382883
- TRPA1 participation in behavioral impairment induced by chronic corticosterone administration. | Pereira, GC., et al. 2023. Psychopharmacology (Berl). 240: 157-169. PMID: 36520197
- TRPA1 as Target in Myocardial Infarction. | Hoebart, C., et al. 2023. Int J Mol Sci. 24: PMID: 36768836
- TRPA1 as a O2 sensor detects microenvironmental hypoxia in the mice anterior cingulate cortex. | Kawabata, R., et al. 2023. Sci Rep. 13: 2960. PMID: 36807332
- Molecular mechanism of hyperactivation conferred by a truncation of TRPA1. | Bali, A., et al. 2023. Nat Commun. 14: 2867. PMID: 37208332
Inhibitor of:
ANKTM1, FABP12, KCC2, MrgA3, MrgA4, MrgA6, MrgA8, MrgH, MRGX, Olfr1166, Olfr324, Olfr536, Olfr722, OR2S2, OR51I, OTRPC4, PLEKHG1, TMEM120B, TRPV3, V1RL5, and Vmn2r99.Activator of:
Olfr1104.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A-967079, 5 mg | sc-363348 | 5 mg | $86.00 | |||
A-967079, 25 mg | sc-363348A | 25 mg | $365.00 | |||
A-967079, 100 mg | sc-363348B | 100 mg | $924.00 |