TMEM118 Inhibitors
The chemical classification referred to as TMEM118 Inhibitors predominantly encompasses compounds that target general cellular processes and pathways which might indirectly influence TMEM118, a transmembrane protein with a yet-to-be-fully characterized function. Given its transmembrane nature, TMEM118's activity, localization, or stability can be influenced by the state and dynamics of the cellular lipid bilayer. Compounds such as Nystatin, Filipin III, and Methyl-β-cyclodextrin play a pivotal role in disrupting lipid bilayer integrity or modulating cholesterol levels, factors which might affect the proper functioning or localization of TMEM118.
Further, considering the cellular processes that typically involve transmembrane proteins, vesicle trafficking and endocytosis play a significant role. Brefeldin A, known to influence vesicle trafficking, and Chlorpromazine, which interferes with clathrin-mediated endocytosis, can modify the turnover or cellular distribution of TMEM118. On another front, ion balance and gradients across membranes are crucial for various cellular activities. Chemicals like Amiloride, Monensin, FCCP, and DIDS disrupt ion channels, transport, and gradients, which could indirectly modulate the function or signaling associated with TMEM118.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nystatin | 1400-61-9 | sc-212431 sc-212431A sc-212431B sc-212431C | 5 MU 25 MU 250 MU 5000 MU | $50.00 $126.00 $246.00 $3500.00 | 7 | |
Disrupts lipid bilayer integrity, which can influence transmembrane protein function. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Ion channel inhibitor which can affect general transmembrane protein activities. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Affects vesicle trafficking, potentially influencing TMEM118's localization or function. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Interferes with clathrin-mediated endocytosis, which can influence transmembrane protein turnover. | ||||||
Filipin III | 480-49-9 | sc-205323 sc-205323A | 500 µg 1 mg | $116.00 $145.00 | 26 | |
Disrupts cholesterol in membranes, possibly affecting TMEM118's localization or stability. | ||||||
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $25.00 $65.00 $170.00 $110.00 | 19 | |
Depletes cholesterol from membranes, potentially affecting transmembrane protein function. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Ionophore that disrupts ion gradients across membranes, which might impact transmembrane proteins like TMEM118. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
Uncouples oxidative phosphorylation; can influence general membrane protein functions by disrupting ion gradients. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Calcium channel blocker that might affect TMEM118 if it plays a role in calcium signaling. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Tyrosine kinase inhibitor, influencing cellular pathways and possibly indirectly affecting TMEM118. | ||||||