TMEFF2 Inhibitors
TMEFF2 Inhibitors belong to a specific chemical class of compounds that have garnered considerable attention in the field of molecular biology and drug discovery. These inhibitors target the Transmembrane Protein with EGF-Like and Two Follistatin-like Domains 2, commonly referred to as TMEFF2. TMEFF2 is a transmembrane protein that plays a crucial role in various cellular processes, including cell growth, differentiation, and signal transduction. To understand the significance of TMEFF2 Inhibitors, it's essential to delve into the structure and function of TMEFF2 itself.
TMEFF2, as the name suggests, contains two follistatin-like domains and an epidermal growth factor (EGF)-like domain. These domains are implicated in protein-protein interactions and signaling pathways. TMEFF2 is often expressed in various tissues and has been associated with regulating cell proliferation and migration. TMEFF2 Inhibitors are chemical compounds designed to specifically target and modulate the activity of TMEFF2. By binding to TMEFF2 or interfering with its signaling pathways, these inhibitors have the potential to impact cellular processes that rely on TMEFF2, although their precise mechanisms and downstream effects may vary. Researchers are actively exploring the development and use of TMEFF2 Inhibitors to better understand the function of TMEFF2 and its potential implications in various cellular contexts. This chemical class holds promise in unraveling the complexities of cellular signaling pathways and may contribute to advancements in the field of molecular biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. TMEFF2 has been shown to regulate EGFR signaling, and inhibition of EGFR can downregulate TMEFF2 expression. | ||||||
Erlotinib, Free Base | 183321-74-6 | sc-396113 sc-396113A sc-396113B sc-396113C sc-396113D | 500 mg 1 g 5 g 10 g 100 g | $85.00 $132.00 $287.00 $495.00 $3752.00 | 42 | |
Erlotinib is another EGFR tyrosine kinase inhibitor, which can indirectly affect TMEFF2 by inhibiting the EGFR pathway, potentially reducing TMEFF2-mediated signaling. | ||||||
Lapatinib | 231277-92-2 | sc-353658 | 100 mg | $412.00 | 32 | |
Lapatinib is a dual tyrosine kinase inhibitor that targets both EGFR and HER2/neu. By inhibiting these receptors, it can indirectly decrease TMEFF2 activity if TMEFF2 is part of the downstream signaling. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Sorafenib is a kinase inhibitor that targets multiple receptors, including VEGFR, PDGFR, and Raf kinases. It may alter TMEFF2 function indirectly through the inhibition of pathways that interact with TMEFF2. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a multi-targeted inhibitor of BCR-ABL and Src family kinases. Given the complexity of kinase signaling networks, dasatinib can alter TMEFF2 signaling indirectly. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid that has been found to modulate various signaling pathways, including those that may involve TMEFF2. It can inhibit kinase activity and affect TMEFF2 indirectly. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
PD168393 is an irreversible inhibitor of EGFR tyrosine kinase. By inhibiting EGFR, it can indirectly influence TMEFF2 expression and activity. | ||||||
SU 5402 | 215543-92-3 | sc-204308 sc-204308A | 1 mg 5 mg | $62.00 $96.00 | 36 | |
SU5402 is a potent and selective inhibitor of FGF receptor tyrosine kinase. If TMEFF2 is involved in FGF signaling, SU5402 can indirectly inhibit TMEFF2 activity. | ||||||
Stat3 Inhibitor VI, S3I-201 | 501919-59-1 | sc-204304 | 10 mg | $148.00 | 104 | |
S3I-201 is a selective inhibitor of Stat3, a transcription factor involved in various signaling pathways. If TMEFF2 is regulated by or regulates Stat3 activity, S3I-201 can indirectly affect TMEFF2. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK, a kinase involved in the MAPK/ERK pathway. As TMEFF2 may have roles in this pathway, U0126 can indirectly inhibit TMEFF2 signaling. | ||||||