TLR4 Activators
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LPS | sc-3535 sc-3535A sc-3535B | 10 mg 25 mg 100 mg | $110.00 $230.00 $415.00 | 111 | ||
LPS, a potent ligand for TLR4, is a complex glycolipid that triggers robust immune responses through its unique structural motifs. Its lipid A component interacts specifically with TLR4, leading to receptor dimerization and activation of downstream signaling cascades, including NF-κB and MAPK pathways. This interaction promotes the release of pro-inflammatory cytokines, shaping the immune landscape. LPS's structural variability among bacterial species influences its immunogenicity and receptor affinity, highlighting its role in pathogen recognition. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $96.00 $166.00 $459.00 $1615.00 | 12 | |
LPS is a component of the outer membrane of Gram-negative bacteria. It activates TLR4 by binding to the MD-2/TLR4 receptor complex, triggering an inflammatory response. | ||||||
Lipopolysaccharide, Re 595 | sc-221856 | 5 mg | $325.00 | |||
Lipopolysaccharide (LPS) serves as a critical activator of TLR4, engaging in intricate molecular interactions that initiate immune signaling. Its unique lipid A structure facilitates receptor clustering, which is essential for the activation of various intracellular pathways, including the production of reactive oxygen species. The distinct fatty acid composition of LPS influences its binding affinity and stability, affecting the kinetics of immune responses and the overall inflammatory milieu. This variability underscores its role in modulating host-pathogen interactions. | ||||||
Kdo2-Lipid A | 123621-04-5 (free base) | sc-396556 | 1 mg | $204.00 | 1 | |
Kdo2-Lipid A (CAS 123621-04-5) functions as a TLR4 inhibitor, modulating immune response via interaction with Toll-like receptor 4, impacting cellular signaling. | ||||||
Resatorvid | 243984-11-4 | sc-476758 | 5 mg | $360.00 | ||
This small molecule compound selectively inhibits TLR4 signaling by binding to a specific region of the TLR4 receptor, preventing its activation in response to LPS. | ||||||
R-848 | 144875-48-9 | sc-203231 sc-203231A sc-203231B sc-203231C | 5 mg 25 mg 100 mg 500 mg | $100.00 $300.00 $500.00 $1528.00 | 12 | |
R-848 is a synthetic compound. It activates TLR4 indirectly by promoting the release of pro-inflammatory cytokines, which can lead to TLR4 activation. | ||||||
Pam3Cys-Ser-(Lys)4, Hydrochloride | 112208-00-1 | sc-507471 | 2 mg | $550.00 | ||
Pam3CSK4 is a synthetic triacylated lipopeptide. It activates TLR4 by binding to TLR2/TLR1 heterodimers, leading to TLR4 activation indirectly through a cross-talk mechanism. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $66.00 $278.00 | 6 | |
Imiquimod is a synthetic compound used in topical creams. It activates TLR4 indirectly by promoting the release of cytokines and chemokines that can activate TLR4 signaling pathways. | ||||||
Gardiquimod | 1020412-43-4 | sc-221663 sc-221663A sc-221663B sc-221663C sc-221663D sc-221663E sc-221663F | 25 mg 50 mg 100 mg 250 mg 5 g 10 g 25 g | $154.00 $276.00 $506.00 $1154.00 $19743.00 $32136.00 $69366.00 | 1 | |
Gardiquimod is a synthetic compound. It can activate TLR4 indirectly by promoting the release of cytokines and chemokines that activate TLR4 signaling pathways. | ||||||