Molecular structure of Kdo2-Lipid A, CAS Number: 123621-04-5 (free base)
Kdo2-Lipid A (CAS 123621-04-5 (free base))
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Alternate Names:
(3-Deoxy-D-manno-octulosonic acid)2-Lipid A
Application:
Kdo2-Lipid A is a TLR4 activator
CAS Number:
123621-04-5 (free base)
Molecular Weight:
2326.64
Molecular Formula:
C110H198N2Na4O39P2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Kdo2-Lipid A is a potent agonist of Toll-like receptor 4 (TLR4), which plays a role in the innate immune response. It activates TLR4 signaling by binding to the MD-2 co-receptor, leading to the recruitment of adaptor proteins and the subsequent activation of downstream signaling pathways, including NF-κB and MAPK. This activation results in the production of pro-inflammatory cytokines and chemokines, contributing to the initiation and regulation of the immune response. Kdo2-Lipid A may induce the maturation and activation of antigen-presenting cells, such as dendritic cells, further enhancing the immune response.
Kdo2-Lipid A (CAS 123621-04-5 (free base)) References
- Mass spectrometry advances in lipidomica: collision-induced decomposition of Kdo2-lipid A. | Murphy, RC., et al. 2005. Prostaglandins Other Lipid Mediat. 77: 131-40. PMID: 16099398
- Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. | Raetz, CR., et al. 2006. J Lipid Res. 47: 1097-111. PMID: 16479018
- Kdo2-lipid A, a TLR4-specific agonist, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy. | Sims, K., et al. 2010. J Biol Chem. 285: 38568-79. PMID: 20876532
- Evolution of the Kdo2-lipid A biosynthesis in bacteria. | Opiyo, SO., et al. 2010. BMC Evol Biol. 10: 362. PMID: 21106097
- [Kdo2-lipid A modification in gram-negative bacteria--a review]. | Wang, X. 2013. Wei Sheng Wu Xue Bao. 53: 111-7. PMID: 23627103
- A combined omics study on activated macrophages--enhanced role of STATs in apoptosis, immunity and lipid metabolism. | Dinasarapu, AR., et al. 2013. Bioinformatics. 29: 2735-43. PMID: 23981351
- Construction and characterization of an Escherichia coli mutant producing Kdo₂-lipid A. | Wang, J., et al. 2014. Mar Drugs. 12: 1495-511. PMID: 24633251
- Kdo2 -lipid A: structural diversity and impact on immunopharmacology. | Wang, X., et al. 2015. Biol Rev Camb Philos Soc. 90: 408-27. PMID: 24838025
- 5-Lipoxygenase activating protein (FLAP) dependent leukotriene biosynthesis inhibition (MK591) attenuates Lipid A endotoxin-induced inflammation. | Fang, WF., et al. 2014. PLoS One. 9: e102622. PMID: 25025775
- Kdo hydroxylase is an inner core assembly enzyme in the Ko-containing lipopolysaccharide biosynthesis. | Chung, HS., et al. 2014. Biochem Biophys Res Commun. 452: 789-94. PMID: 25204504
- Highly Sensitive Detection and Differentiation of Endotoxins Derived from Bacterial Pathogens by Surface-Enhanced Raman Scattering. | Wu, X., et al. 2021. Biosensors (Basel). 11: PMID: 34356705
- PCSK9 Promotes Endothelial Dysfunction During Sepsis Via the TLR4/MyD88/NF-κB and NLRP3 Pathways. | Huang, L., et al. 2023. Inflammation. 46: 115-128. PMID: 35930089
- SILAC-based quantitative proteomics to investigate the eicosanoid associated inflammatory response in activated macrophages. | Brace, N., et al. 2022. J Inflamm (Lond). 19: 12. PMID: 36050729
- Lipid Microenvironment Modulates the Pore-Forming Ability of Polymyxin B. | Zakharova, AA., et al. 2022. Antibiotics (Basel). 11: PMID: 36290103
Activator of:
TLR4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Kdo2-Lipid A, 1 mg | sc-396556 | 1 mg | $208.00 |