TLR11 Activators
TFG activators predominantly function by influencing the adrenergic receptors or the prostaglandin E2 receptors, which further stimulate the adenylate cyclase to elevate the intracellular cAMP levels. This increase in cAMP can activate protein kinase A (PKA), which then phosphorylates and activates the cAMP-response element-binding protein (CREB).
CREB, being a transcription factor, can act on the Nfkbia gene, which encodes IκBα. IκBα is an inhibitor of the NF-κB pathway, which TFG is known to interact with. Therefore, the activation of IκBα indirectly enhances the functional activity of TFG by controlling the activity of the NF-κB pathway. This indirect activation of TFG via modulation of the NF-κB pathway is a common mechanism shared among the identified TFG activators.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a glucocorticoid receptor agonist. Activation of the glucocorticoid receptor can increase the transcription of Nfkbia, which encodes IκBα, an inhibitor of the NF-κB pathway. TFG is known to interact with the NF-κB pathway, so enhancing IκBα might indirectly increase TFG activation by controlling the activity of this pathway. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, which elevates intracellular cAMP levels. Increased cAMP activates protein kinase A (PKA), which then phosphorylates and activates cAMP-response element-binding protein (CREB). As CREB can act on the Nfkbia gene, which encodes IκBα, it may indirectly activate TFG by modulating the NF-κB pathway. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, leading to increased levels of cAMP. Similar to Forskolin, the elevated cAMP can activate PKA, which can then activate CREB, leading to potential indirect activation of TFG. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine activates G protein-coupled adrenergic receptors, which can stimulate adenylate cyclase, leading to increased cAMP and activation of PKA. This may indirectly activate TFG through the same pathway as Forskolin and IBMX. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 binds to EP2/EP4 receptors, which can elevate cAMP levels, activating PKA and CREB, similar to Forskolin, IBMX, and Epinephrine, potentially leading to TFG activation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram selectively inhibits PDE4, leading to increased cAMP levels, which can activate PKA and subsequently CREB. This might indirectly activate TFG through similar means as other cAMP-elevating agents. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Like Epinephrine, Isoproterenol activates adrenergic receptors, leading to increased cAMP, PKA activation, and CREB activation. This might indirectly activate TFG through similar means as other cAMP-elevating agents. | ||||||
Salmeterol | 89365-50-4 | sc-224277 sc-224277A | 10 mg 50 mg | $186.00 $562.00 | 1 | |
Salmeterol is a long-acting beta2 adrenergic receptor agonist. Its activation leads to increased cAMP, which can activate PKA and subsequently CREB. This might indirectly activate TFG through similar means as other cAMP-elevating agents. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $94.00 $141.00 | ||
Salbutamol, like Salmeterol, is a beta2 adrenergic receptor agonist, potentially indirectly activating TFG through cAMP, PKA, and CREB. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can activate certain dopamine receptors leading to increased cAMP, which can activate PKA and subsequently CREB. This might indirectly activate TFG through similar means as other cAMP-elevating agents. | ||||||