Salmeterol CAS: 89365-50-4
MF: C25H37NO4
MW: 415.57
A potent and selective β2-AR agonist.

Salmeterol (CAS 89365-50-4)

Salmeterol | CAS 89365-50-4 is rated 5.0 out of 5 by 1.
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Alternate Names: Astmerole; Serevent; Aeromax
Application: Salmeterol is a potent and selective β2-AR agonist
CAS Number: 89365-50-4
Purity: ≥98%
Molecular Weight: 415.57
Molecular Formula: C25H37NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Salmeterol is a potent and selective β2-AR adrenoceptor agonist (EC50 = 5.3 nM) that displays bronchodilator actions. Unlike other β2-AR agonists, Salmeterol binds to exo-site domain of β2-AR receptors, producing a slow onset of action and prolonged activation.


References

Johnson et al (1993) The pharmacology of salmeterol. Life Sci. 52 2131. Ellis et al (1995) Correlation of cyclic AMP accumulation and relaxant actions of salmeterol and salbutamol in bovine tracheal smooth muscle. Br.J.Pharmacol. 116 2510. Clark et al (1996) Stable activation and desensitization of beta 2-adrenergic receptor stimulation of adenylyl cyclase by salmeterol: evidence for quasi-irreversible binding to an exosite. Mol.Pharmacol. 49 182.

Physical State :
Solid
Solubility :
Soluble in ethanol (50 mM), and DMSO (100 mM).
Storage :
Store at 4° C
Melting Point :
243.54° C (Predicted)
Boiling Point :
~603.0° C at 760 mmHg (Predicted)
Density :
~1.1 g/mL (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
β-2 adrenergic receptor: IC50 = 3.5 nM (guinea pig); β2-AR: IC50 = 5.01 nM (human); Electrically induced contraction of superfused guinea-pig trachea: IC50 = 15 nM (rat); β1-AR: IC50 = 501.19 nM (human); Antiplasmodial activity against Plasmodium falciparum W2: IC50 = 6.31 µM
Ki Data :
β2-AR: Ki= 0.39 nM (human); β1-AR: Ki= 801 nM (human)
pK Values :
pKa: 9.99 (Predicted), pKb: 9.26 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
CZ6457000
PubChem CID :
5152
MDL Number :
MFCD00867037
SMILES :
C1=CC=C(C=C1)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O

Download SDS (MSDS)

Certificate of Analysis

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Salmeterol (CAS 89365-50-4)  Product Citations

See how others have used Salmeterol (CAS 89365-50-4). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 30664786  Liu, PH.|Shah, RB.|Li, Y.|Arora, A.|Ung, PM.|Raman, R.|Gorbatenko, A.|Kozono, S.|Zhou, XZ.|Brechin, V.|Barbaro, JM.|Thompson, R.|White, RM.|Aguirre-Ghiso, JA.|Heymach, JV.|Lu, KP.|Silva, JM.|Panageas, KS.|Schlessinger, A.|Maki, RG.|Skinner, HD.|de Stanchina, E.|Sidi, S.| et al. 2019. Nat. Cell Biol.

Citations 1 to 1 of 1 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Salmeterol, sc-224277, is in white or off-white powder form.
Answered by: Chemical Support 4
Date published: 2017-07-07
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Rated 5 out of 5 by from Manoharan et al Manoharan et al. (PubMed ID 2620533) used salmeterol, a potent and selective 2-AR agonist, to treat persistent asthma and found it to improve impulse oscillometry. -SCBT Publication Review
Date published: 2015-05-20
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