Molecular structure of Salmeterol, CAS Number: 89365-50-4
Salmeterol (CAS 89365-50-4)
See product citations (1)
Alternate Names:
Astmerole; Serevent; Aeromax
Application:
Salmeterol is a potent and selective β2-AR agonist
CAS Number:
89365-50-4
Purity:
≥98%
Molecular Weight:
415.57
Molecular Formula:
C25H37NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Salmeterol interacts with β2-adrenergic receptors found on the outer layer of airway smooth muscle cells. This interaction triggers the receptor′s activation, subsequently stimulating adenylyl cyclase, an enzyme that enhances the generation of cAMP. The increased levels of cAMP then initiate the activation of protein kinase A, resulting in the relaxation of airway smooth muscle cells and ultimately leading to bronchodilation.
Salmeterol (CAS 89365-50-4) References
- Fluticasone/salmeterol reduces remodelling and neutrophilic inflammation in severe equine asthma. | Bullone, M., et al. 2017. Sci Rep. 7: 8843. PMID: 28821845
- Mechanisms of β-adrenergic receptors agonists in mediating pro and anti-apoptotic pathways in hyperglycemic Müller cells. | Safi, SZ., et al. 2022. Mol Biol Rep. 49: 9473-9480. PMID: 35925485
- Inhibition of VMAT2 by β2-adrenergic agonists, antagonists, and the atypical antipsychotic ziprasidone. | Støve, SI., et al. 2022. Commun Biol. 5: 1283. PMID: 36418492
- Kinetic analysis of endogenous β2 -adrenoceptor-mediated cAMP GloSensor™ responses in HEK293 cells. | Cullum, SA., et al. 2022. Br J Pharmacol.. PMID: 36495270
- Optical photothermal infrared spectroscopy for nanochemical analysis of pharmaceutical dry powder aerosols. | Khanal, D., et al. 2023. Int J Pharm. 632: 122563. PMID: 36586629
- Corticosteroid-LABA inhalers increase phonation threshold pressure (PTP) and flow (PTF) in rabbits. | Tanner, K., et al. 2023. Laryngoscope.. PMID: 36757019
- Dysfunction of the noradrenergic system drives inflammation, α-synucleinopathy, and neuronal loss in mouse colon. | Song, S., et al. 2023. Front Immunol. 14: 1083513. PMID: 36845109
Inhibitor of:
GPR158, Olfr1, Olfr1018, Olfr151, Olfr224, Olfr265, Olfr829, Olfr883, Olr1076, Olr1096, Olr1104, Olr1228, Olr1425, Olr1431, Olr1433, Olr1488, Olr1519, Olr1520, Olr1545, Olr1546, Olr1547, Olr1559, Olr1567, Olr1569, Olr1593, Olr1602, Olr1639, Olr1640, Olr1664, Olr226, Olr23, Olr25, Olr3, Olr336, Olr358, Olr401, Olr404, Olr552, Olr657, Olr709, Olr713, Olr747, Olr792, Olr804, Olr840, Olr905, OR5K1, and XCR1 (X-C motif chemokine receptor 1).Activator of:
β-Arrestin-2, β-sarcoglycan, β2-AR, alpha2A-AR, Bcy1, beta2-AR, CKR-8, Factor I, frizzled-10, G β1, GAIP, GHRH-R, GPCR2037, GPR114, GPR61, GRK 3, MBD3L1, Med29, NELL2, Olfr1061, OR4A16, OR4F17, OR4S2, PC1, RAMP2, RRP12, SMOC-2, SSTR5, TLR11, and V1RA4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Salmeterol, 10 mg | sc-224277 | 10 mg | $186.00 | |||
Salmeterol, 50 mg | sc-224277A | 50 mg | $562.00 |