TLE4 Inhibitors
TLE4 inhibitors are a class of chemical compounds specifically designed to target and inhibit the function of Transducin-Like Enhancer of Split 4 (TLE4), a transcriptional corepressor that plays a significant role in regulating gene expression during various cellular processes, including development, differentiation, and cell fate determination. TLE4 is a member of the Groucho/TLE family of proteins, which are known for their ability to interact with DNA-bound transcription factors and repress the transcription of target genes. This repression is typically achieved through the recruitment of histone deacetylases (HDACs) and other chromatin remodeling complexes that modify the chromatin structure, leading to a more condensed state that is less accessible for transcriptional machinery. By inhibiting TLE4, researchers can disrupt these repressive activities, thereby altering the expression of genes involved in critical developmental and cellular pathways.
In research settings, TLE4 inhibitors are valuable tools for probing the mechanisms by which TLE4 regulates gene expression and contributes to cellular differentiation and development. By blocking TLE4 activity, scientists can study the impact on gene expression profiles, particularly focusing on how the loss of TLE4-mediated repression affects the activation of specific genes and the resulting cellular outcomes. This can include investigating changes in cell identity, lineage specification, and the overall dynamics of developmental processes. Additionally, TLE4 inhibitors allow researchers to explore the interactions between TLE4 and other transcriptional regulators, providing insights into the complex networks of protein-protein interactions that govern gene repression and activation. Through these studies, TLE4 inhibitors contribute to a deeper understanding of the role of transcriptional corepressors in cellular regulation, the importance of epigenetic modifications in controlling gene expression, and the broader implications of TLE4 function in the context of development and cellular differentiation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
XAV939 is a tankyrase inhibitor that indirectly modulates TLE4 by stabilizing Axin1. By inhibiting tankyrase, XAV939 prevents Axin1 degradation, enhancing the destruction complex's activity and reducing TLE4 association with β-catenin. This indirect modulation can impact Wnt signaling and potentially affect TLE4 expression or function. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
GSI-IX (DAPT) is a gamma-secretase inhibitor that directly modulates TLE4 by inhibiting Notch signaling. By blocking gamma-secretase activity, GSI-IX prevents the cleavage of Notch, reducing the release of the Notch intracellular domain (NICD). This inhibits Notch-mediated transcriptional activation and can influence TLE4 expression or function. | ||||||
β-Catenin/Tcf Inhibitor, FH535 | 108409-83-2 | sc-221398 sc-221398A | 10 mg 50 mg | $182.00 $374.00 | 7 | |
FH535 is a dual inhibitor that indirectly modulates TLE4 by targeting the Wnt/β-catenin and PPARγ signaling pathways. By inhibiting β-catenin and PPARγ, FH535 can disrupt TLE4's association with β-catenin and alter its transcriptional activity. This dual impact provides an alternative approach to influence TLE4 expression or function by modulating multiple signaling pathways simultaneously. | ||||||
KY02111 | 1118807-13-8 | sc-397043 sc-397043A | 5 mg 25 mg | $79.00 $336.00 | ||
KY02111 is a Wnt/β-catenin signaling inhibitor that directly modulates TLE4 by disrupting the interaction between β-catenin and TLE4. By inhibiting Wnt/β-catenin signaling, KY02111 prevents the nuclear translocation of β-catenin and reduces its association with TLE4. | ||||||
PRI-724 | 1422253-38-0 | sc-507535 | 25 mg | $260.00 | ||
PRI-724 is a CBP/β-catenin antagonist that indirectly modulates TLE4 by disrupting the interaction between CBP and β-catenin. By inhibiting this interaction, PRI-724 interferes with β-catenin-mediated transcription, potentially affecting TLE4 expression or function. This indirect modulation provides an avenue to influence TLE4 through specific disruption of the CBP/β-catenin complex. | ||||||
Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $214.00 $326.00 $1275.00 | 1 | |
C59 is a tankyrase inhibitor that indirectly modulates TLE4 by stabilizing Axin1. By inhibiting tankyrase, C59 prevents Axin1 degradation, enhancing the destruction complex's activity and reducing TLE4 association with β-catenin. This indirect modulation can impact Wnt signaling and potentially affect TLE4 expression or function. | ||||||