The chemical class of TLE3 Activators comprises agents that affect cellular pathways in which TLE3 is a player. Retinoic Acid, for instance, acts by activating retinoic acid receptors that affect gene transcription, diminishing TLE3's co-repressive functions. Dexamethasone is another compound affecting gene transcription but operates through the glucocorticoid receptor. These chemicals often indirectly affect TLE3 by either modifying the activity of transcription factors it interacts with or by altering the chromatin landscape in which it operates. For example, Trichostatin A is an HDAC inhibitor that can modify chromatin structure, influencing the repression mediated by TLE3.
Forskolin and Rapamycin are particularly notable because they affect broad cellular pathways and thus have more wide-ranging impacts. Forskolin raises intracellular cAMP levels, affecting a multitude of transcription factors that may work in tandem with TLE3. Rapamycin affects mTOR signaling, a pathway known to influence a broad array of cellular functions, including transcription. Sulforaphane modulates the NRF2 signaling pathway, known to regulate oxidative stress and involving TLE3 as a corepressor. These chemicals vary in their initial targets but converge in influencing transcriptional landscapes where TLE3 operates as a corepressor.
Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Activates retinoic acid receptors, affecting pathways where TLE3 acts as a co-repressor. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Glucocorticoid receptor agonist affecting transcriptional regulation involving TLE3. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK-3β affecting Wnt signaling, in which TLE3 may play a role as a co-repressor. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Raises intracellular cAMP levels, potentially affecting transcription factors working with TLE3. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Modifies NRF2 signaling, affecting pathways in which TLE3 is involved as a corepressor. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor affecting ERK signaling, which may indirectly influence TLE3 activity. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
Inhibits TGF-beta signaling affecting transcription factors that can work with TLE3. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor that may modulate transcriptional processes in which TLE3 participates. |