TLE3 Inhibitors
Common TLE3 Inhibitors include, but are not limited to Curcumin CAS 458-37-7, Retinoic Acid, all trans CAS 302-79-4, Dexamethasone CAS 50-02-2, Valproic Acid CAS 99-66-1 and 5-Azacytidine CAS 320-67-2.
The TLE3 (Transducin-Like Enhancer of Split 3) protein is a part of the TLE family, which consists of transcriptional corepressors. These proteins have an essential role in various cellular processes, including cell fate determination, neurogenesis, and the segmentation process during embryogenesis. TLE proteins are known to exert their repressive effects by associating with a range of transcription factors, effectively preventing them from activating their target genes. The TLE3, in particular, has been implicated in various cellular mechanisms and pathways, making it a subject of interest in cellular biology and molecular studies.
TLE3 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of the TLE3 protein. These inhibitors are designed to bind to TLE3, disrupting its ability to interact with its partner transcription factors or other associated proteins. By doing so, these inhibitors can modulate the transcriptional repression effects of TLE3, leading to altered expression patterns of various target genes. The molecular structures of TLE3 inhibitors are tailored to ensure high specificity towards TLE3, with minimal interactions with other proteins or cellular components. This specificity ensures that the effects observed upon administering these inhibitors can be attributed directly to the modulation of TLE3 activity
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may reduce TLE3 expression by modulating transcriptional activity and interfering with associated signaling pathways. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid, a histone deacetylase inhibitor, might suppress TLE3 expression by altering chromatin accessibility and transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, could alter TLE3 expression by changing DNA methylation patterns. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, might reduce TLE3 expression by changing chromatin structure and transcriptional regulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin could modulate TLE3 expression through its effects on the mTOR pathway. | ||||||
Bicalutamide | 90357-06-5 | sc-202976 sc-202976A | 100 mg 500 mg | $41.00 $143.00 | 27 | |
Bicalutamide, an androgen receptor antagonist, might affect TLE3 expression in contexts where androgen signaling plays a role. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid, a histone deacetylase inhibitor, can potentially suppress TLE3 expression by changing chromatin accessibility. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib, a proteasome inhibitor, might affect TLE3 degradation and thereby its expression levels in cells. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine, a DNA methyltransferase inhibitor, could modulate TLE3 expression through changes in DNA methylation. | ||||||