Date published: 2026-4-27

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Valproic Acid (CAS 99-66-1)

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Alternate Names:
2-Propylpentanoic Acid
Application:
Valproic Acid is A branched chain fatty acid
CAS Number:
99-66-1
Purity:
≥98%
Molecular Weight:
144.21
Molecular Formula:
C8H16O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Valproic Acid is a widely studied chemical in various research disciplines, particularly in the field of biochemistry and neuroscience. In research laboratories, Valproic Acid is often used to probe the mechanisms of gene expression regulation, as it is known to act as a histone deacetylase (HDAC) inhibitor, affecting chromatin structure and function. This activity allows scientists to study epigenetic modifications and their consequences on cellular processes. In addition, Valproic Acid is used in neuroscientific research to understand the modulation of neurotransmitter pathways and ion channel function. Its influence on GABAergic transmission is of particular interest in studies of neural networks and signaling. Researchers also explore the effects of Valproic Acid on neural plasticity and differentiation, providing insights into the molecular underpinnings of neural development and connectivity.


Valproic Acid (CAS 99-66-1) References

  1. Actions of sodium valproate on the central nervous system.  |  Tunnicliff, G. 1999. J Physiol Pharmacol. 50: 347-65. PMID: 10574466
  2. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen.  |  Phiel, CJ., et al. 2001. J Biol Chem. 276: 36734-41. PMID: 11473107
  3. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells.  |  Göttlicher, M., et al. 2001. EMBO J. 20: 6969-78. PMID: 11742974
  4. Valproic acid, a molecular lead to multiple regulatory pathways.  |  Kostrouchová, M., et al. 2007. Folia Biol (Praha). 53: 37-49. PMID: 17448293
  5. Valproic acid-induced neural tube defects in mouse and human: aspects of chirality, alternative drug development, pharmacokinetics and possible mechanisms.  |  Nau, H., et al. 1991. Pharmacol Toxicol. 69: 310-21. PMID: 1803343
  6. Valproic acid-associated vanishing bile duct syndrome.  |  Gökçe, S., et al. 2010. J Child Neurol. 25: 909-11. PMID: 20388938
  7. Neurophysiological and biochemical changes evoked by valproic acid in the central nervous system.  |  Cotariu, D., et al. 1990. Prog Neurobiol. 34: 343-54. PMID: 2110371
  8. Valproic acid as an adjunctive therapeutic agent for the treatment of breast cancer.  |  Heers, H., et al. 2018. Eur J Pharmacol. 835: 61-74. PMID: 30075223
  9. Valproic Acid Significantly Improves CRISPR/Cas9-Mediated Gene Editing.  |  Park, H., et al. 2020. Cells. 9: PMID: 32532133
  10. Insights into Structural Modifications of Valproic Acid and Their Pharmacological Profile.  |  Mishra, MK., et al. 2021. Molecules. 27: PMID: 35011339
  11. Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid.  |  Vrijenhoek, NG., et al. 2022. ALTEX. 39: 207–220. PMID: 35040482
  12. Effect of long-term valproic acid therapy on lipid profiles in paediatric patients with epilepsy: a meta-analysis.  |  Guo, HL., et al. 2022. Epileptic Disord. 24: 822-830. PMID: 35816100
  13. Modelling of the pharmacodynamic interaction between phenytoin and sodium valproate.  |  Della Paschoa, OE., et al. 1998. Br J Pharmacol. 125: 1610-6. PMID: 9884091

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Valproic Acid, 10 g

sc-213144
10 g
$87.00