TISP74 Inhibitors
TISP74 inhibitors are a class of chemical compounds designed to specifically target and inhibit the activity of the TISP74 protein, a protein potentially involved in transcriptional regulation and other critical cellular processes. These inhibitors function by binding to key regions of the TISP74 protein, such as its active site or DNA-binding domain, preventing the protein from interacting with its natural substrates or molecular partners. By occupying these regions, TISP74 inhibitors effectively block the protein's ability to regulate gene expression or participate in other biological functions. Additionally, some TISP74 inhibitors may act through allosteric inhibition, where they bind to sites away from the active domain and induce conformational changes that reduce or eliminate the protein's activity. The binding of these inhibitors is stabilized by non-covalent forces, including hydrogen bonds, hydrophobic interactions, van der Waals forces, and electrostatic interactions, ensuring that the inhibitors remain firmly bound to the protein and disrupt its function effectively.
The structural diversity of TISP74 inhibitors is a key factor in their ability to interact with specific regions of the protein. These inhibitors often contain functional groups such as hydroxyl, carboxyl, or amine groups, which allow them to form hydrogen bonds and ionic interactions with amino acid residues in the TISP74 binding pockets. Many TISP74 inhibitors also incorporate aromatic rings or heterocyclic structures, which enhance hydrophobic interactions with non-polar regions of the protein, further stabilizing the inhibitor-protein complex. The physicochemical properties of these inhibitors, such as molecular weight, solubility, lipophilicity, and polarity, are carefully optimized to ensure that they bind effectively and remain stable in various biological environments. This balance of hydrophilic and hydrophobic regions allows TISP74 inhibitors to engage both polar and non-polar regions of the protein, ensuring selective and robust inhibition of TISP74 activity across a variety of cellular conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D may inhibit sperm microtubule inner protein 4 (SMC4) expression by inhibiting RNA polymerase activity, thus preventing transcription of the SMC4 gene and reducing its expression at the mRNA level. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide may inhibit sperm microtubule inner protein 4 (SMC4) expression by inhibiting protein synthesis, which could lead to reduced translation of SMC4 mRNA into protein, consequently lowering SMC4 expression levels. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin may inhibit sperm microtubule inner protein 4 (SMC4) expression by inhibiting RNA polymerase II activity, which could prevent transcription initiation of the SMC4 gene, leading to reduced mRNA levels and subsequent decrease in SMC4 protein expression. | ||||||
Azadirachtin | 11141-17-6 | sc-257105 sc-257105A sc-257105B sc-257105C sc-257105D | 1 mg 5 mg 10 mg 25 mg 50 mg | $177.00 $374.00 $626.00 $999.00 $1727.00 | ||
Azadirachtin may inhibit sperm microtubule inner protein 4 (SMC4) expression by modulating transcription factors or coactivators involved in the regulation of SMC4 gene expression. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin may inhibit sperm microtubule inner protein 4 (SMC4) expression by inhibiting topoisomerase I activity, leading to DNA damage and activation of DNA damage response pathways, which could downregulate SMC4 gene transcription and subsequently decrease SMC4 expression. | ||||||
Emetine | 483-18-1 | sc-470668 sc-470668A sc-470668B sc-470668C | 1 mg 10 mg 50 mg 100 mg | $440.00 $900.00 $1400.00 $2502.00 | ||
Emetine may inhibit sperm microtubule inner protein 4 (SMC4) expression by inhibiting protein synthesis, which could lead to reduced translation of SMC4 mRNA into protein, consequently lowering SMC4 expression levels. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil may inhibit sperm microtubule inner protein 4 (SMC4) expression by interfering with nucleic acid synthesis, leading to DNA and RNA damage, which could trigger cellular responses that downregulate SMC4 gene expression and reduce SMC4 protein levels. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $166.00 $322.00 | 436 | |
Puromycin may inhibit sperm microtubule inner protein 4 (SMC4) expression by causing premature termination of protein synthesis, leading to reduced translation of SMC4 mRNA into protein and consequent decrease in SMC4 expression levels. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin may inhibit sperm microtubule inner protein 4 (SMC4) expression by inhibiting bacterial RNA polymerase, which might indirectly affect SMC4 expression by interfering with mitochondrial function or signaling pathways associated with SMC4 regulation. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Sorafenib may inhibit sperm microtubule inner protein 4 (SMC4) expression by interfering with signaling pathways involved in cell proliferation and survival, which could indirectly affect SMC4 expression levels through downstream regulatory mechanisms. | ||||||