TIS11D Activators
TIS11D Activators is a class of chemicals that influence the functional activity of the RNA-binding protein TIS11D. These compounds typically function by enhancing the role of TIS11D in post-transcriptional regulation of gene expression, particularly through the mechanism of PKA-dependent phosphorylation.
he chemicals in this class primarily influence the intracellular levels of cAMP and the activity of protein kinase A (PKA), both of which are intrinsically tied to the functional activation of TIS11D. Some of these chemicals, such as Forskolin, IBMX, Rolipram, 8-Br-cAMP, Sp-cAMP, Dibutyryl-cAMP, and 6-Bnz-cAMP, enhance TIS11D's functional activity by increasing the activity of PKA, which is known to phosphorylate TIS11D.
On the other hand, we have chemicals like H-89, PKA Inhibitor Fragment (6-22) amide, KT5720, and Rp-8-Br-cAMPS that function as inhibitors of PKA. Counterintuitively, these PKA inhibitors can indirectly enhance the functional activity of TIS11D. They achieve this by reducing the phosphorylation of other substrates, thereby freeing up PKA to phosphorylate TIS11D. It's a strategic diversion of PKA resources towards TIS11D, thereby increasing its functional activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, which increases the intracellular levels of cAMP. TIS11D is known to be regulated via PKA-dependent phosphorylation, which is activated via cAMP. Thus, Forskolin can enhance the functional activity of TIS11D by activating adenylate cyclase and thereby increasing PKA-dependent phosphorylation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor that increases the intracellular levels of cAMP. Similar to Forskolin, IBMX can enhance the functional activity of TIS11D by increasing the levels of cAMP, leading to PKA-dependent phosphorylation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase-4 which leads to an increase in cAMP concentrations. As cAMP stimulates PKA, which in turn phosphorylates TIS11D, Rolipram can indirectly enhance the functional activity of TIS11D. | ||||||
PKI (6-22) amide | 121932-06-7 | sc-201160 | 1 mg | $160.00 | 11 | |
This PKA inhibitor reduces the phosphorylation of other substrates of PKA, thereby indirectly enhancing the functional availability of PKA for TIS11D phosphorylation. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) is a cell-permeable cAMP analog that activates PKA. By activating PKA, it can enhance the functional activity of TIS11D, which is known to be regulated via PKA-dependent phosphorylation. | ||||||
Sp-cAMPS | 93602-66-5 | sc-201571 | 1 mg | $97.00 | 3 | |
Sp-cAMP is a cAMP analog that activates PKA. By increasing PKA activity, it can enhance the functional activity of TIS11D through PKA-dependent phosphorylation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA. It can enhance the functional activity of TIS11D by promoting PKA-dependent phosphorylation. | ||||||
KT 5720 | 108068-98-0 | sc-3538 sc-3538A sc-3538B | 50 µg 100 µg 500 µg | $138.00 $220.00 $972.00 | 47 | |
KT 5720 is a potent and selective inhibitor of PKA. By inhibiting PKA, it reduces the phosphorylation of other substrates, thereby enhancing the functional availability of PKA for TIS11D phosphorylation. | ||||||
Rp-8-Br-cAMPS | 129735-00-8 | sc-3539A sc-3539 | 500 µg 1 mg | $250.00 $340.00 | 22 | |
Rp-8-Br-cAMPS is a potent inhibitor of PKA. By inhibiting PKA, it reduces the phosphorylation of other substrates, thereby enhancing the functional availability of PKA for TIS11D phosphorylation. | ||||||