TIPIN Inhibitors
TIPIN (Timeless Interacting Protein) inhibitors belong to a distinctive class of chemical compounds that target a specific cellular pathway crucial for the regulation of DNA replication and cell cycle progression. The TIPIN protein, an integral component of the Timeless-TIPIN complex, plays a pivotal role in the maintenance of genomic stability by facilitating the proper orchestration of DNA replication fork progression. The inhibition of TIPIN function is of particular interest in the realm of molecular biology and cell biology, as it offers a means to modulate the intricate processes involved in DNA replication.
Structurally, TIPIN inhibitors are designed to interact with the TIPIN protein or disrupt the formation of the Timeless-TIPIN complex, thereby interfering with its ability to interact with other key players in the DNA replication machinery. By selectively targeting this protein-protein interaction, TIPIN inhibitors have the potential to perturb the normal dynamics of DNA replication, leading to downstream effects on cellular processes such as cell division and genomic stability. The development and study of TIPIN inhibitors represent a significant advancement in the understanding of the molecular mechanisms governing DNA replication, providing researchers with valuable tools to unravel the intricacies of this fundamental biological process. The exploration of TIPIN inhibitors offers insights into the delicate balance required for precise DNA replication and contributes to the broader scientific goal of deciphering the molecular intricacies that govern cellular functions at the genetic level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
UCN-01 | 112953-11-4 | sc-202376 | 500 µg | $251.00 | 10 | |
A staurosporine analog that inhibits CHK1, potentially disrupting the interaction with TIPIN and replication fork stabilization. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
A selective ATR inhibitor that can perturb the ATR-TIPIN interaction crucial for cell cycle checkpoint control. | ||||||
NU6027 | 220036-08-8 | sc-215591 | 10 mg | $156.00 | 1 | |
Inhibits CDK2, which is involved in cell cycle regulation and may indirectly affect TIPIN function associated with the replication fork. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $110.00 | 28 | |
An ATM inhibitor that can influence the DNA damage response pathway and indirectly the TIPIN-related processes. | ||||||
KU 60019 | 925701-46-8 | sc-363284 sc-363284A | 10 mg 50 mg | $248.00 $1035.00 | 1 | |
Similar to KU-55933, this ATM inhibitor can alter the cascade in which TIPIN operates. | ||||||
AZD7762 | 860352-01-8 | sc-364423 | 2 mg | $107.00 | ||
A CHK1 inhibitor that would disrupt the CHK1-TIPIN interaction involved in DNA damage response. | ||||||
SCH 900776 | 891494-63-6 | sc-364611 sc-364611A | 5 mg 10 mg | $255.00 $338.00 | ||
Another CHK1 inhibitor which, by affecting CHK1, might alter TIPIN's role in checkpoint regulation. | ||||||
PF 477736 | 952021-60-2 | sc-362781 sc-362781A | 5 mg 25 mg | $115.00 $431.00 | ||
A CHK1 inhibitor, potentially affecting TIPIN's interaction in the DNA damage checkpoint response. | ||||||
LY2603618 | 911222-45-2 | sc-364526 sc-364526A | 5 mg 50 mg | $214.00 $1809.00 | ||
Inhibits CHK1 and might interfere with the recruitment of TIPIN to the replication fork. | ||||||
MRN-ATM Pathway Inhibitor, Mirin | 299953-00-7 | sc-203144 | 10 mg | $141.00 | 4 | |
Inhibits MRE11, affecting the MRN complex which is upstream of TIPIN and may indirectly impact its function in DNA damage response. | ||||||