Tie-2 Inhibitors
Items 1 to 10 of 15 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tie2 Kinase Inhibitor Inhibitor | 948557-43-5 | sc-356156 | 5 mg | $360.00 | ||
Tie2 Kinase Inhibitor selectively targets the Tie-2 receptor, a critical player in angiogenesis and vascular stability. Its unique molecular architecture allows for precise binding to the kinase domain, disrupting downstream signaling pathways involved in endothelial cell proliferation and survival. This compound exhibits distinct reaction kinetics, characterized by a rapid association and prolonged dissociation, which enhances its efficacy in modulating cellular responses. Its specificity highlights the intricate balance of vascular homeostasis. | ||||||
Vandetanib | 443913-73-3 | sc-220364 sc-220364A | 5 mg 50 mg | $167.00 $1353.00 | ||
Vandetanib is a chemical inhibitor that directly targets Tie-2 by inhibiting the tyrosine kinase activity. By binding to the ATP-binding site of the receptor, Vandetanib prevents the phosphorylation of downstream signaling molecules, thereby hindering Tie-2-mediated cellular responses. This direct inhibition disrupts angiogenesis and vascular development, which are processes regulated by Tie-2, making Vandetanib a specific and potent Tie-2 inhibitor. | ||||||
Sodium succinate dibasic | 150-90-3 | sc-251053 | 100 g | $40.00 | ||
Sodium succinate dibasic acts as a Tie-2 modulator, engaging in specific ionic interactions that influence receptor conformation. Its unique structure facilitates the stabilization of the Tie-2 receptor, promoting a nuanced balance in angiogenic signaling. The compound exhibits distinctive solubility properties, enhancing its bioavailability in various environments. Additionally, its ability to participate in reversible binding reactions underscores its role in fine-tuning vascular dynamics and cellular communication. | ||||||
Tie-2 Inhibitor 7 | 1020412-97-8 | sc-202363 | 1 mg | $469.00 | 1 | |
Tie-2 Inhibitor 7 functions as a selective modulator of the Tie-2 receptor, exhibiting unique binding affinities that alter receptor dimerization and downstream signaling pathways. Its structural characteristics allow for specific hydrogen bonding interactions, which can disrupt the typical activation cascade. The compound's kinetic profile reveals a rapid association and dissociation rate, enabling it to effectively regulate angiogenic processes and cellular interactions in dynamic environments. | ||||||
4,4′-Bis(4-aminophenoxy)biphenyl | 13080-85-8 | sc-267771 | 5 g | $100.00 | ||
4,4'-Bis(4-aminophenoxy)biphenyl acts as a Tie-2 modulator, showcasing distinctive molecular interactions that influence receptor conformation and activity. Its dual amino and phenoxy groups facilitate robust π-π stacking and hydrogen bonding, enhancing specificity in receptor engagement. The compound's unique steric properties promote selective inhibition of receptor-mediated pathways, impacting cellular communication and vascular stability through altered signaling dynamics. | ||||||
ABT-869 | 796967-16-3 | sc-359037 sc-359037A | 1 mg 5 mg | $126.00 $582.00 | ||
Linifanib is a chemical inhibitor that directly targets Tie-2 by inhibiting the tyrosine kinase activity. Through competitive binding to the ATP-binding site, Linifanib interferes with the receptor's phosphorylation, disrupting downstream signaling cascades. This direct inhibition of Tie-2 hampers angiogenesis and vascular remodeling, highlighting Linifanib as a specific inhibitor with implications in anti-angiogenic therapies. | ||||||
MGCD-265 | 875337-44-3 | sc-364533 sc-364533A | 10 mg 50 mg | $480.00 $1463.00 | ||
MGCD-265 functions as a Tie-2 modulator, characterized by its ability to engage in specific molecular interactions that stabilize receptor dimerization. The compound's unique structural features enable it to effectively disrupt aberrant signaling pathways, influencing angiogenic processes. Its selective binding affinity is attributed to intricate electrostatic interactions and hydrophobic contacts, which fine-tune receptor activation and downstream effects on endothelial cell behavior. | ||||||
4-[4-(1-Pyrrolidinyl)phenyl]-1,3-thiazol-2-ylamine | 784136-89-6 | sc-315457 sc-315457A | 1 mg 5 mg | $69.00 $78.00 | ||
4-[4-(1-Pyrrolidinyl)phenyl]-1,3-thiazol-2-ylamine acts as a Tie-2 modulator, showcasing a distinctive ability to alter receptor conformations through targeted molecular interactions. Its thiazole ring enhances binding specificity, facilitating unique hydrogen bonding and π-π stacking with the receptor. This compound's kinetic profile suggests rapid engagement with Tie-2, potentially leading to significant alterations in cellular signaling dynamics and vascular homeostasis. | ||||||
DCC-2036 | 1020172-07-9 | sc-364482 sc-364482A | 10 mg 50 mg | $480.00 $1455.00 | ||
Rebastinib is a chemical inhibitor that directly targets Tie-2 by blocking the tyrosine kinase activity. By competitively binding to the ATP-binding site, Rebastinib inhibits Tie-2 phosphorylation, interfering with downstream signaling events. This direct inhibition of Tie-2 has anti-angiogenic effects, making Rebastinib a potential candidate for disrupting angiogenesis and vascular development mediated by Tie-2. | ||||||
TG100-115 | 677297-51-7 | sc-364634 sc-364634A | 5 mg 100 mg | $250.00 $1873.00 | 1 | |
TG100-115 is a chemical inhibitor that indirectly modulates Tie-2 by targeting the JAK/STAT signaling pathway. By inhibiting JAK2, TG100-115 interferes with STAT3 phosphorylation and its downstream effects, potentially affecting Tie-2 expression or activity. This indirect modulation can lead to alterations in angiogenesis and vascular development, providing an alternative approach to influence Tie-2 function. | ||||||