Date published: 2025-12-14

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Tie2 Kinase Inhibitor Inhibitor (CAS 948557-43-5)

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Alternate Names:
4-(6-Methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole
Application:
Tie2 Kinase Inhibitor is a cell-permeable inhibitor of Tie2
CAS Number:
948557-43-5
Purity:
≥97%
Molecular Weight:
439.5
Molecular Formula:
C26H21N3O2S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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The Tie2 Kinase Inhibitor is a specialized compound engineered to specifically target and suppress the Tie2 kinase enzyme, which is essential in the angiogenesis process, the formation of new blood vessels. This inhibition is significant for researching vascular biology and potentially influencing conditions characterized by abnormal vessel growth. The compound operates by binding to Tie2 kinase′s active site, thereby halting its enzymatic function and the downstream signaling pathways that promote blood vessel development and stability. This action is for exploring the mechanisms of blood vessel formation and could contribute to understanding how to manage abnormal angiogenesis in various conditions. The ongoing research into the Tie2 Kinase Inhibitor is aimed at uncovering its detailed effects and its role in advancing the study of vascular dynamics and the control of irregular blood vessel growth in vitro.


Tie2 Kinase Inhibitor Inhibitor (CAS 948557-43-5) References

  1. Pyridinylimidazole inhibitors of Tie2 kinase.  |  Semones, M., et al. 2007. Bioorg Med Chem Lett. 17: 4756-60. PMID: 17618114
  2. Efficacy of Tie2 receptor antagonism in angiosarcoma.  |  Hasenstein, JR., et al. 2012. Neoplasia. 14: 131-40. PMID: 22431921
  3. Plasma Fibronectin Promotes Tumor Cell Survival and Invasion through Regulation of Tie2.  |  Knowles, LM., et al. 2013. J Cancer. 4: 383-90. PMID: 23833683
  4. Angiopoetin-2 Signals Do Not Mediate the Hypervascularization of Islets in Type 2 Diabetes.  |  Shah, P., et al. 2016. PLoS One. 11: e0161834. PMID: 27617438
  5. Dengue virus or NS1 protein induces trans-endothelial cell permeability associated with VE-Cadherin and RhoA phosphorylation in HMEC-1 cells preventable by Angiopoietin-1.  |  Singh, S., et al. 2018. J Gen Virol. 99: 1658-1670. PMID: 30355397
  6. Thrombin promotes pericyte coverage by Tie2 activation in a rat model of intracerebral hemorrhage.  |  Hu, E., et al. 2019. Brain Res. 1708: 58-68. PMID: 30527680
  7. Genetics of vascular malformation and therapeutic implications.  |  Zúñiga-Castillo, M., et al. 2019. Curr Opin Pediatr. 31: 498-508. PMID: 31246627

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tie2 Kinase Inhibitor, 5 mg

sc-356156
5 mg
$360.00