Molecular structure of Tie-2 Inhibitor 7, CAS Number: 1020412-97-8
Tie-2 Inhibitor 7 (CAS 1020412-97-8)
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Alternate Names:
5-[4-[[[2-[[(1S)-1-Cyclohexylethyl]amino]-2-oxoethyl][(4-methylphenoxy)carbonyl]amino]methyl]phenyl]-3-pyridinecarboxylic acid
Application:
Tie-2 Inhibitor 7 is an agent that inhibits endothelial cell tube formation
CAS Number:
1020412-97-8
Purity:
≥95%
Molecular Weight:
523.58
Molecular Formula:
C31H29N3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
The Tie-2 Inhibitor 7 can permeate the cell (IC50= 1uM) and inhibit edothelial cell tube formation. Research shows that it can block the Tie-2 ligand, Ang-1 (angiopoietin), which induces Tie2 autophosphorylation and block its downstream signaling with an IC(50)= 0.3 microM. Vascular leakage, suppression of endothelial apoptosis, and vessel regression are strongly inhibited by Ang-1. The Tie 2 receptor plays a crucial role in the normal and pathologic vascular development of epithelial cells.
Tie-2 Inhibitor 7 (CAS 1020412-97-8) References
- Identification and characterization of small-molecule inhibitors of Tie2 kinase. | Liu, J., et al. 2008. FEBS Lett. 582: 785-91. PMID: 18267118
- Roles of the receptor tyrosine kinases Tie1 and Tie2 in mediating the effects of angiopoietin-1 on endothelial permeability and apoptosis. | Milner, CS., et al. 2009. Microvasc Res. 77: 187-91. PMID: 18848573
- Tie2 in tumor endothelial signaling and survival: implications for antiangiogenic therapy. | Tsai, JH. and Lee, WM. 2009. Mol Cancer Res. 7: 300-10. PMID: 19276184
Inhibitor of:
Tie-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tie-2 Inhibitor 7, 1 mg | sc-202363 | 1 mg | $469.00 |