Tie-2 Inhibitor 7 CAS: 1020412-97-8
MF: C31H29N3O5
MW: 523.58
An agent that inhibits endothelial cell tube formation.

Tie-2 Inhibitor 7 (CAS 1020412-97-8)

Tie-2 Inhibitor 7 | CAS 1020412-97-8 is rated 5.0 out of 5 by 1.
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Alternate Names: 5-[4-[[[2-[[(1S)-1-Cyclohexylethyl]amino]-2-oxoethyl][(4-methylphenoxy)carbonyl]amino]methyl]phenyl]-3-pyridinecarboxylic acid
Application: Tie-2 Inhibitor 7 is an agent that inhibits endothelial cell tube formation
CAS Number: 1020412-97-8
Purity: ≥95%
Molecular Weight: 523.58
Molecular Formula: C31H29N3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
DISCOUNT: Bulk orders of Chemicals totaling $1,000 or more receive a 5% discount.
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Tie-2 Inhibitor 7 can permeate the cell (IC50= 1μM) and inhibit endothelial cell tube formation. Research shows that it can block the Tie-2 ligand, Ang-1 (angiopoietin), which induces Tie-2 autophosphorylation and block its downstream signaling with an IC50= 0.3 μM. Vascular leakage, suppression of endothelial apoptosis, and vessel regression are strongly inhibited by Ang-1. The Tie-2 receptor plays a crucial role in the normal and pathologic vascular development of epithelial cells.


References

1. Liu, J., et al. 2008. FEBS Lett. 582: 785-791. PMID: 18267118
2. Milner, C.S., et al. 2009. Microvasc. Res. 77: 187-191. PMID: 18848573
3. Tsai, J.H., et al. 2009. Mol. Cancer Res. 7: 300-310. PMID: 19276184

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml).
Storage :
Store at -20° C
Boiling Point :
~788.3° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
Cc1ccc(cc1)OC(=O)N(Cc1ccc(cc1)c1cncc(c1)C(=O)O)CC(=O)N[[email protected]@H](C)c1ccccc1

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Certificate of Analysis

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Tie-2 Inhibitor 7 (CAS 1020412-97-8)  Product Citations

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PMID: # 19276184  Tsai, JH. et al. 2009. Mol. Cancer Res. 7: 300-310.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Tie Tie-2 Inhibitor 7 was reported in many articles as an inhibitor endothelial cell tube formation in epithelial cells. -SCBT Publication Review
Date published: 2015-05-02
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