Thrombospondin 3 Inhibitors
Thrombospondin 3 inhibitors are a class of chemical compounds designed to target and modulate the activity of the Thrombospondin 3 protein, also known as THBS3. Thrombospondin 3 is a member of the thrombospondin family of extracellular matrix (ECM) proteins, which are primarily found in connective tissues and play significant roles in various cellular processes, including cell adhesion, migration, and tissue remodeling. THBS3, specifically, is associated with the modulation of cell-matrix interactions and is expressed in various tissues, including the heart, skeletal muscle, and lung. Inhibitors of Thrombospondin 3 are developed to interfere with its function or activity, affecting cell adhesion, ECM remodeling, and other processes governed by this protein.
The mechanisms by which Thrombospondin 3 inhibitors function can vary based on their chemical structures and binding properties. Some inhibitors may directly interact with Thrombospondin 3, preventing its binding to cell surface receptors or other ECM components. Others may modulate the conformation or stability of Thrombospondin 3, affecting its ability to influence cell adhesion, migration, or ECM organization. By inhibiting Thrombospondin 3, these compounds have the to disrupt the ECM-related processes in various tissues, which can impact tissue homeostasis and remodeling. Ongoing research in this field aims to elucidate the precise mechanisms and downstream effects of Thrombospondin 3 inhibition, contributing to our understanding of its role in cellular biology and tissue function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triamcinolone acetonide | 76-25-5 | sc-205872 sc-205872A | 50 mg 250 mg | $57.00 $152.00 | ||
A glucocorticoid that can regulate gene expression by interacting with glucocorticoid receptors, potentially downregulating THBS3. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C leading to altered gene expression, which may include the downregulation of THBS3. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that could alter downstream AKT signaling and potentially impact THBS3 transcription. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
Inhibits p38 MAPK signaling which may influence THBS3 expression by affecting transcriptional regulation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A MAPK/ERK inhibitor which could potentially downregulate THBS3 expression through the inhibition of the ERK pathway. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Inhibits aldehyde dehydrogenase, potentially affecting signaling pathways and gene expression, possibly including THBS3. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $71.00 $296.00 $612.00 | 19 | |
Inhibits NF-κB signaling, which could potentially downregulate THBS3 expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
An NRF2 activator that may modulate the expression of various genes, including potentially THBS3. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Another glucocorticoid known to affect gene expression through glucocorticoid receptors, possibly reducing THBS3 levels. | ||||||