TGN38B Inhibitors
Chemical inhibitors of TGN38B can disrupt the protein's function by targeting various elements of the cellular machinery involved in protein trafficking and sorting. Manumycin A and FTI-277 work by selectively inhibiting enzymes like farnesyltransferase, a critical modifier of the Ras protein, which plays a significant role in signaling pathways that guide the localization and function of TGN38B. Similarly, GGTI-298 hampers the function of Rab proteins by preventing geranylgeranylation, a post-translational modification necessary for their activity. This disruption can indirectly affect the trafficking pathways that are crucial for the proper functioning of TGN38B. Meanwhile, SecinH3 targets cytohesins, disrupting ARF GTPase activity, which can lead to compromised vesicular trafficking and sorting, processes in which TGN38B is heavily involved.
Further affecting TGN38B's role in trafficking, ML141 acts as a Cdc42 inhibitor, impeding the regulation of vesicular trafficking, while compounds like Exo1 and Dyngo-4a inhibit Exo70 and dynamin, respectively, disrupting processes essential for vesicle tethering and release. CID-1067700 broadly disrupts the function of multiple GEFs for small GTPases, which are integral for the proper regulation of vesicular trafficking and protein sorting. This can lead to a chain of events culminating in the impairment of TGN38B's sorting functions. Additionally, Brefeldin A and Pitstop 2 interfere with the Golgi apparatus structure and clathrin-mediated endocytosis, respectively, both essential for the proper localization and function of TGN38B in protein sorting pathways. Lastly, BI-D1870's inhibition of RSK and Latrunculin B's disruption of actin polymerization can indirectly impair TGN38B by affecting the signaling pathways and cytoskeletal organization necessary for its function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $215.00 $622.00 | 5 | |
Manumycin A selectively inhibits Ras farnesyltransferase, an enzyme required for the proper localization and function of Ras proteins. TGN38B is involved in trafficking and sorting of proteins from the trans-Golgi network; inhibition of Ras can disrupt the trafficking pathways in which TGN38B functions. | ||||||
FTI-277 trifluoroacetate salt | 170006-73-2 (free base) | sc-215058 sc-215058A | 1 mg 5 mg | $160.00 $581.00 | 1 | |
FTI-277 is a farnesyltransferase inhibitor that prevents the farnesylation of Ras, thereby blocking its activation. Without active Ras, intracellular signaling necessary for proper function and localization of TGN38B may be disrupted. | ||||||
GGTI 298 | 1217457-86-7 | sc-361184 sc-361184A | 1 mg 5 mg | $189.00 $822.00 | 2 | |
GGTI-298 is a geranylgeranyltransferase inhibitor. By inhibiting geranylgeranylation, it impairs the function of Rab proteins, which can indirectly inhibit TGN38B by disrupting vesicular trafficking processes that TGN38B is associated with. | ||||||
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $273.00 | 6 | |
SecinH3 inhibits cytohesins, which are GDP-GTP exchange factors for ARF GTPases. ARF GTPases are involved in the regulation of vesicular trafficking, which is crucial for TGN38B function; thus, SecinH3 indirectly inhibits TGN38B by impairing vesicular trafficking. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
ML141 is a Cdc42 inhibitor, and Cdc42 is a small GTPase involved in the regulation of vesicular trafficking. By inhibiting Cdc42, ML141 can indirectly inhibit TGN38B function by disrupting vesicular transport and sorting mechanisms. | ||||||
Exo1 | 461681-88-9 | sc-200752 sc-200752A | 10 mg 50 mg | $82.00 $291.00 | 4 | |
Exo1 is an inhibitor of Exo70, a component of the exocyst complex involved in tethering vesicles to the plasma membrane. Inhibition of Exo1 leads to impaired vesicle tethering and indirectly inhibits TGN38B by disrupting the secretory pathway. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A inhibits ADP-ribosylation factor (ARF), which is necessary for the maintenance of Golgi structure and function. Inhibiting ARF leads to Golgi disassembly, which can indirectly inhibit TGN38B by disrupting its localization and function in protein sorting. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Pitstop 2 is a clathrin inhibitor that blocks the formation of clathrin-coated pits. Since TGN38B is involved in protein trafficking, inhibition of clathrin-mediated endocytosis can indirectly inhibit the function of TGN38B in the cell. | ||||||
BI-D1870 | 501437-28-1 | sc-397022 sc-397022A | 1 mg 5 mg | $90.00 $275.00 | 12 | |
BI-D1870 is an inhibitor of RSK (p90 ribosomal S6 kinase), which is involved in a variety of cellular processes including protein sorting. By inhibiting RSK, BI-D1870 can indirectly inhibit TGN38B by disrupting signaling pathways involved in vesicular trafficking. | ||||||
Latrunculin B | 76343-94-7 | sc-203318 | 1 mg | $229.00 | 29 | |
Latrunculin B disrupts actin polymerization, which is critical for vesicular movement and cytoskeletal organization. This disruption can indirectly inhibit TGN38B by impairing the vesicular transport functions in which TGN38B is involved. | ||||||