TGIF2 Inhibitors
TGIF2 inhibitors belong to a specialized class of chemical compounds designed to target the TGIF2 (Transforming Growth Factor Beta-Induced Factor 2) protein. TGIF2 is a transcriptional repressor that plays a role in regulating gene expression, particularly in response to signaling pathways involving transforming growth factor-beta (TGF-β). It belongs to the TALE (three-amino acid loop extension) family of homeodomain transcription factors. TGIF2 is known to interact with various cellular proteins and participate in the modulation of gene transcription, contributing to a wide range of biological processes, including embryonic development, cell proliferation, and differentiation.
Inhibitors of TGIF2 are designed to interact with this protein and disrupt its transcriptional regulatory functions. These inhibitors may operate through various mechanisms, such as binding to specific domains of TGIF2 or altering its interactions with other transcriptional regulators. By inhibiting TGIF2, these compounds can affect the expression of target genes controlled by TGIF2, influencing cellular processes associated with TGF-β signaling and gene regulation. Research on TGIF2 inhibitors is primarily focused on elucidating the molecular mechanisms by which TGIF2 functions as a transcriptional repressor and its role in various cellular contexts, offering insights into the broader landscape of gene regulation and its implications for development and cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A-366 | 1527503-11-2 | sc-507495 | 10 mg | $195.00 | ||
A selective G9a/GLP histone lysine methyltransferase inhibitor, which may alter gene expression including TGIF2. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
A diazepin-quinazolin-amine derivative that inhibits G9a HMTase, potentially affecting TGIF2 transcription. | ||||||
UNC0638 | 1255580-76-7 | sc-397012 | 10 mg | $315.00 | ||
A potent G9a and GLP inhibitor that can affect chromatin methylation and consequently gene expression profiles. | ||||||
Epz004777 | 1338466-77-5 | sc-507560 | 100 mg | $575.00 | ||
A specific inhibitor of DOT1L histone H3K79 methyltransferase, potentially impacting transcription including TGIF2. | ||||||
I-CBP112 | 1640282-31-0 | sc-507494 | 25 mg | $400.00 | ||
Designed to inhibit the CREBBP/EP300 bromodomains, possibly affecting expression of certain genes including TGIF2. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
A small molecule inhibitor targeting BET bromodomains, leading to changes in gene expression including potential TGIF2 downregulation. | ||||||
RVX 208 | 1044870-39-4 | sc-472700 | 10 mg | $340.00 | ||
Targets the BET domain of BRD4, potentially impacting the transcription of various genes, possibly including TGIF2. | ||||||
PFI-1 | 1403764-72-6 | sc-478504 | 5 mg | $98.00 | ||
A potent BET bromodomain inhibitor which may affect chromatin remodeling and gene expression. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
A benzamide HDAC inhibitor that might indirectly suppress TGIF2 expression by modifying chromatin. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
An isotype-selective HDAC inhibitor that could modulate gene expression profiles, potentially affecting TGIF2. | ||||||