TFIIIC90 Activators
TFIIIC90 activators encompass a unique set of chemicals, primarily drawn towards influencing transcriptional pathways, particularly revolving around Pol III, where GTF3C4 plays its primary role. Leading the list is DrB, recognized for inhibiting RNA Pol II. The inhibition of Pol II can indirectly steer the transcriptional machinery towards Pol III, bringing GTF3C4 into prominence. Actinomycin D, with its transcription-interfering abilities, and Mithramycin A, which binds to DNA and modulates RNA synthesis, further exemplify the intricate network of transcription regulation that might indirectly affect GTF3C4.
Triptolide's ability to stifle RNA Pol II, similar to DrB, suggests a potential elevation in Pol III transcription, drawing parallels in their method of action. Leptomycin B, by affecting nuclear retention, might indirectly control the localization and functionality of GTF3C4. Transcription, at its core, is intertwined with chromatin structure. Trichostatin A, a histone deacetylase inhibitor, illustrates this connection, hinting at an indirect influence on GTF3C4 through chromatin remodeling. The story gains complexity with α-Amanitin, another Pol II inhibitor, underscoring the balance between different RNA polymerases. Genistein, Caffeine, Wortmannin, U0126, and Rapamycin weave a broader tale, with each affecting various cellular pathways, which can indirectly converge on transcriptional dynamics and subsequently on GTF3C4's role.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
Known inhibitor of RNA Pol II can indirectly upregulate Pol III, potentially affecting GTF3C4’s activity. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Interferes with the transcription process and can alter Pol III transcription, potentially affecting GTF3C4. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Binds to DNA and inhibits RNA synthesis, potentially causing compensatory effects that could influence GTF3C4 indirectly. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Inhibits RNA Pol II transcription, which might indirectly boost Pol III transcription and affect GTF3C4. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
Known nuclear export inhibitor; might impact nuclear retention of factors and influence GTF3C4. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Histone deacetylase inhibitor can modulate transcription and potentially influence GTF3C4 indirectly. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
A strong inhibitor of Pol II; this can indirectly modulate Pol III activity, and thereby affect GTF3C4. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Tyrosine kinase inhibitor that can have broad effects on cellular transcription, potentially affecting GTF3C4 indirectly. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Affects multiple cellular pathways and can influence transcription, potentially having an indirect effect on GTF3C4. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3K inhibitor that can modulate cellular transcription processes, potentially influencing GTF3C4. | ||||||