TESSP6 Inhibitors
Chemical inhibitors of TESSP6 include a variety of compounds that target specific kinases and signaling pathways upon which TESSP6 relies for its activity. Staurosporine is a well-known kinase inhibitor that interrupts the phosphorylation processes, which are critical for the functional activity of many proteins, including TESSP6. By inhibiting these kinases, Staurosporine can prevent the activation or inactivation of TESSP6 that is dependent on phosphorylation. Similarly, Wortmannin and LY294002 are inhibitors of PI3K, a kinase that participates in a multitude of cellular pathways. Since TESSP6 operates within signaling networks that may be regulated by PI3K, the inhibition of this kinase by Wortmannin or LY294002 can lead to a direct decrease in TESSP6 activity by halting the signals that provoke its action.
In the same vein, Bisindolylmaleimide I and SP600125 target other key kinases within cellular signaling networks. Bisindolylmaleimide I inhibits Protein Kinase C (PKC), and SP600125 targets JNK. If TESSP6 is situated downstream of PKC or JNK, the inhibition of these kinases would result in the suppression of TESSP6 activity by preventing the requisite phosphorylation events. Other kinase inhibitors like SB203580, U0126, and PD98059 disrupt the MAPK pathway at different points. SB203580 inhibits p38 MAPK, while both U0126 and PD98059 target MEK, an upstream regulator of ERK, which may be essential for the activation of TESSP6. By blocking these kinases, these inhibitors can prevent the phosphorylation and subsequent activation of TESSP6. Rapamycin, which inhibits mTOR, a central controller of cell growth, could suppress TESSP6 activity if TESSP6 is involved in mTOR-regulated pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine can inhibit TESSP6 by targeting protein kinases that TESSP6 is dependent on for its activity. This broad-spectrum kinase inhibitor can disrupt phosphorylation events needed for TESSP6 function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits PI3K, a kinase involved in numerous signaling pathways. Since TESSP6 is part of signaling cascades that can be regulated by PI3K activity, wortmannin can inhibit TESSP6 function by blocking the kinase it relies upon. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another PI3K inhibitor which can inhibit TESSP6 by halting the PI3K-dependent pathways necessary for TESSP6's role in signal transduction. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
This compound inhibits Protein Kinase C (PKC), and if TESSP6 is regulated by PKC-mediated signaling, its inhibition can result in reduced TESSP6 activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor. Should TESSP6 operate downstream of JNK in cellular signaling, this inhibitor can suppress TESSP6 by preventing its activation through JNK signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK. If TESSP6's function is modulated by p38 MAPK signaling, then inhibiting this kinase can lead to the functional inhibition of TESSP6. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK, which is upstream of ERK in the MAPK pathway. Inhibiting MEK, and consequently ERK activity, can inhibit TESSP6 if it is part of the ERK signaling pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is another MEK inhibitor, functioning similarly to U0126. It can also inhibit TESSP6 by blocking the MEK-ERK signaling pathway that may be crucial for TESSP6's role. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is a central regulator of cell growth and proliferation. TESSP6, if involved in mTOR signaling, would be functionally inhibited as a result of mTOR inhibition. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an Src family kinase inhibitor. If TESSP6 is functionally linked to Src signaling, PP2 can inhibit TESSP6 by disrupting Src kinase activity. | ||||||