tepsin Inhibitors
Tepsin inhibitors like compounds like Brefeldin A, Monensin, and Golgicide A disrupt the structure and function of the Golgi apparatus and endosomes, which are critical for the endosome-to-Golgi retrieval pathway that tepsin is known to participate in. The integrity and function of these organelles are essential for tepsin to mediate its role in cargo selection and sorting.
Additionally, inhibitors that perturb the cytoskeleton, such as Nocodazole, Cytochalasin D, Latrunculin A, and ML141, alter the transport and organization of vesicles, which is a key aspect of tepsin's involvement in cellular trafficking. Nocodazole and Paclitaxel have opposing effects on microtubules, yet both result in altered vesicle transport dynamics that are necessary for tepsin's function. Cytochalasin D and Latrunculin A target actin filaments, which are also implicated in maintaining the vesicular trafficking pathways where tepsin operates. Other inhibitors, such as Dynasore, Chlorpromazine, and Pitstop 2, specifically target the endocytic machinery. By inhibiting dynamin or blocking clathrin-mediated endocytosis, these compounds can disrupt the endosomal sorting processes that tepsin is a part of. Lastly, Genistein broadly targets signaling pathways by inhibiting tyrosine kinases, leading to alterations in the signaling that may govern tepsin's activity in protein sorting.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Alters Golgi and endosomal structure, thus disrupting the intracellular sorting processes where tepsin is active. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Inhibits dynamin, affecting vesicle scission and potentially influencing tepsin-mediated cargo selection and trafficking. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Disrupts Golgi acidification and vesicle trafficking, impacting the endosomal sorting processes involving tepsin. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Destabilizes microtubules and disrupts vesicle transport mechanisms, which are critical for tepsin function in cargo sorting. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Inhibits actin polymerization, affecting cytoskeletal dynamics and, consequently, tepsin-dependent vesicular trafficking. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Disrupts actin filaments, which can alter the endosomal sorting and trafficking functions where tepsin operates. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Blocks clathrin-mediated endocytosis, potentially altering the endosomal cargo selection and sorting roles of tepsin. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Inhibits tyrosine kinases, leading to broad effects on signaling pathways that can affect tepsin-related sorting mechanisms. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Stabilizes microtubules, altering the dynamics of vesicular transport systems that tepsin utilizes for sorting activities. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $191.00 $683.00 | 11 | |
Targets the Golgi and could disrupt the protein sorting and trafficking where tepsin is involved. | ||||||