Tektin 3 Activators

Tektin 3 is a protein that belongs to the tektin family, a group of filament-forming proteins predominantly found in cilia and flagella, where they play a crucial role in the structural integrity and function of these organelles. Tektins are known for forming stable polymers, and they are integrated into the axoneme, the central structural component of cilia and flagella. The axoneme's microtubules are essential for the movement and signaling functions of these cellular structures.

Tektin 3, specifically, is involved in the formation and stabilization of microtubules within cilia and flagella. These structures are critical for various cellular processes, including motility (as seen in sperm cells), sensory functions (like in the olfactory system and in vision), and signaling pathways. Given the importance of cilia in numerous cell types, tektin 3 plays a fundamental role in a wide range of physiological processes.Mutations or dysfunctions in tektin 3 can lead to disorders related to ciliary dysfunction, known as ciliopathies. These conditions can manifest in various ways, depending on which cells or tissues are affected. For instance, defects in sperm flagella due to tektin 3 abnormalities can result in male infertility.