TCTE1 Inhibitors
TCTE1, or T-complex-associated-testis-expressed 1, is a protein that has been primarily associated with ciliary movement and is believed to have a role in the motility of cilia and flagella. Given its association with these cellular structures, TCTE1 is understood to be involved in various cellular processes that rely on ciliary movement, such as the movement of mucus in the respiratory tract or the propulsion of sperm in the reproductive system. The protein's function is believed to be linked to its interactions with other proteins in the T-complex, which is essential for the proper assembly and function of cilia and flagella.
Inhibitors targeting TCTE1 are chemical entities designed to modulate the activity of TCTE1, thereby affecting its role in ciliary and flagellar movement. These inhibitors can operate through various mechanisms. Some might interfere with the protein-protein interactions essential for TCTE1's function within the T-complex. Others might bind directly to TCTE1, altering its conformation and subsequently its activity. The design and development of TCTE1 inhibitors necessitate a profound understanding of the protein's structure and its functional role within cells. By modulating TCTE1 activity, these inhibitors can shed light on the fundamental cellular processes associated with ciliary and flagellar movement, offering insights into the intricate mechanisms that govern these essential cellular structures.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D intercalates between guanine-cytosine base pairs, inhibiting RNA polymerase and halting transcription. This effect may reduce transcriptional activity of the TCTE1 gene. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
A potent inhibitor of RNA polymerase II, α-Amanitin binds to the enzyme and blocks mRNA elongation, which may lead to reduced synthesis of TCTE1 mRNA. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Targets the 60S ribosomal subunit, specifically inhibiting the peptidyl transferase activity, thus preventing translational elongation. This action could impede the translation of TCTE1 mRNA. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a nucleoside analog, it incorporates into DNA and inhibits DNA methyltransferases, leading to hypomethylation. This action might modulate the transcriptional regulation of TCTE1. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
Inhibits inosine-5'-monophosphate dehydrogenase, leading to depletion of the guanine nucleotide pool, which could modulate various cellular transcriptional processes, including that of TCTE1. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
Directly inhibits the phosphorylation of RNA polymerase II, thereby attenuating the transcriptional elongation process, which could affect TCTE1 mRNA synthesis. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Binds to the 60S ribosomal subunit, inhibiting the peptidyl transferase activity, potentially impeding TCTE1 mRNA translation. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Binds to the DNA-topoisomerase I complex, inhibiting the re-ligation step of the DNA cleavage-ligation sequence, potentially impacting TCTE1 gene transcription. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Binds specifically to HSP90, potentially affecting its client proteins' maturation and stability, which might indirectly modulate TCTE1 protein levels. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Inhibits cyclin-dependent kinases necessary for transcriptional progression, which could attenuate the transcriptional activity of TCTE1. | ||||||