TCR γ Inhibitors
TCR γ inhibitors belong to a distinctive chemical class that plays a pivotal role in modulating the activity of T cells, a crucial component of the immune system. T cells, particularly the subset expressing gamma delta T cell receptors (TCR γδ), serve as sentinels, surveying and responding to various antigens. These receptors are instrumental in initiating immune responses against pathogens and abnormal cells. TCR γ inhibitors are designed to specifically target and modulate the function of TCR γδ, influencing downstream signaling pathways associated with immune responses. The mechanism of action of TCR γ inhibitors involves interference with the intricate signaling cascades triggered by TCR γδ engagement.
These inhibitors may exert their effects at different stages of T cell activation, affecting intracellular signaling molecules and pathways that are crucial for T cell function. By doing so, TCR γ inhibitors offer a nuanced approach to modulating immune responses, holding promise for research applications aimed at understanding the complexities of T cell biology. The development and study of TCR γ inhibitors contribute to advancing our comprehension of immune system regulation and may open new avenues for scientific inquiry into the intricacies of T cell signaling and immunomodulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporine is an immunosuppressant that can inhibit calcineurin, a protein required for TCR signal transduction. By doing this, it can indirectly inhibit TCR γ. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $76.00 $148.00 | 9 | |
Tacrolimus also inhibits calcineurin, similar to cyclosporine, hence indirectly inhibiting TCR γ. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a key player in TCR signaling, thus indirectly affecting TCR γ. | ||||||
Sotrastaurin | 425637-18-9 | sc-474229 sc-474229A | 5 mg 10 mg | $300.00 $540.00 | ||
Sotrastaurin is a protein kinase C inhibitor, affecting TCR signaling and therefore TCR γ indirectly. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib inhibits LCK, a tyrosine kinase involved in TCR signaling, thereby indirectly inhibiting TCR γ. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Imatinib can inhibit ABL tyrosine kinases, which are involved in TCR signaling, thereby indirectly inhibiting TCR γ. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a plant flavonoid that can inhibit PI3K, a key player in TCR signaling, thereby indirectly inhibiting TCR γ. | ||||||
Wogonin, S. baicalensis | 632-85-9 | sc-203313 | 10 mg | $200.00 | 8 | |
Wogonin is a flavonoid that can inhibit NF-κB, a transcription factor activated by TCR signaling, and thus indirectly inhibit TCR γ. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein can inhibit tyrosine kinases involved in TCR signaling, thereby indirectly inhibiting TCR γ. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of PI3K, thereby indirectly inhibiting TCR γ through the TCR signaling pathway. | ||||||