TCR γ Antibody (UC3-10A6): sc-19609

TCR γ Antibody (UC3-10A6) is a hamster monoclonal IgG antibody that detects the TCR gamma protein of mouse origin by immunofluorescence (IF). Anti-TCR gamma antibody (UC3-10A6) is available as the non-conjugated format, providing researchers with a reliable tool for studying T cell activation and function. The T cell antigen receptor (TCR) plays a crucial role in the immune response by recognizing foreign antigens and initiating intracellular signaling pathways that lead to T cell activation. The TCR is a heterodimer composed of either alpha and beta or gamma and delta chains, with the majority of T cells expressing the alpha/beta heterodimer. Notably, TCR gamma protein is primarily found in a subset of T cells known as gamma delta T cells, which are important for immune surveillance and can respond to a wide range of antigens, including those not presented by major histocompatibility complex (MHC) molecules. This unique ability allows gamma delta T cells to play a significant role in the early immune response, particularly in tissues where they can rapidly respond to infections or tumors. The TCR, in conjunction with CD3 chains and co-receptors such as CD4 or CD8, ensures efficient signal transduction, enabling T cells to mount an effective immune response. TCR gamma monoclonal antibody (UC3-10A6) helps researchers gain insights into the dynamics of T cell populations and their functional states, ultimately contributing to a better understanding of immune mechanisms and potential therapeutic targets.

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TCR γ Antibody (UC3-10A6) References:

1. Repertoire development and ligand specificity of murine TCR gamma delta cells.  |  Bluestone, JA., et al. 1991. Immunol Rev. 120: 5-33. PMID: 1650760
2. Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding.  |  Healey, D., et al. 1990. J Exp Med. 172: 1233-42. PMID: 1698911
3. The immunobiology of T cells with invariant gamma delta antigen receptors.  |  Allison, JP. and Havran, WL. 1991. Annu Rev Immunol. 9: 679-705. PMID: 1832874
4. Signal transduction by the T cell antigen receptor.  |  Weiss, A., et al. 1991. Semin Immunol. 3: 313-24. PMID: 1839225
5. TCR gamma/delta+ dendritic epidermal T cells as constituents of skin-associated lymphoid tissue.  |  Tigelaar, RE., et al. 1990. J Invest Dermatol. 94: 58S-63S. PMID: 1972173
6. TCR-γ expression in primary cutaneous T-cell lymphomas.  |  Rodríguez-Pinilla, SM., et al. 2013. Am J Surg Pathol. 37: 375-84. PMID: 23348211
7. Identification of the residues in human CD4 critical for the binding of HIV.  |  Arthos, J., et al. 1989. Cell. 57: 469-81. PMID: 2541915
8. Subpopulations of swine γδ T cells defined by TCRγ and WC1 gene expression.  |  Le Page, L., et al. 2021. Dev Comp Immunol. 125: 104214. PMID: 34329647
9. Structure and expression of the human and mouse T4 genes.  |  Maddon, PJ., et al. 1987. Proc Natl Acad Sci U S A. 84: 9155-9. PMID: 3501122
10. The interaction between CD4 and MHC class II molecules and its effect on T cell function.  |  Vignali, DA. 1994. Behring Inst Mitt. 133-47. PMID: 7998907
11. T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen.  |  Ehrich, EW., et al. 1993. J Exp Med. 178: 713-22. PMID: 8393480
12. Distinct roles for CD4 and CD8 as co-receptors in antigen receptor signalling.  |  Julius, M., et al. 1993. Immunol Today. 14: 177-83. PMID: 8499078

The preferred TCR γ/δ antibody is TCR γ/δ Antibody (UC7-13D5): sc-19608.