TCP11L1 Inhibitors
Chemical inhibitors of TCP11L1 are compounds that can indirectly inhibit the functions of this protein by targeting various signaling pathways and enzymes that are involved in cellular processes such as cell cycle regulation, spermatogenesis, and cytoskeletal dynamics. Alsterpaullone and Indirubin-3'-monoxime, both cyclin-dependent kinase inhibitors, can alter the cell cycle regulation by inhibiting kinases that are crucial for the progression of the cell cycle, therefore affecting the role of TCP11L1 in this process. Similarly, Bisindolylmaleimide I, Chelerythrine Chloride, and Gö6976, all of which inhibit protein kinase C, can disrupt the signaling pathways that TCP11L1 is part of, impacting cellular proliferation and differentiation processes where TCP11L1 would normally be involved.
Further affecting the functionality of TCP11L1, LY294002, a PI3K inhibitor, can affect the protein's role by altering downstream signaling events related to cell growth and survival. ML7 hydrochloride can influence cellular movement and structure by inhibiting myosin light chain kinase, which is vital for cytoskeletal dynamics and, consequently, for the function of TCP11L1 in cell motility. PD98059 and U0126 can disrupt the MAPK/ERK pathway by inhibiting MEK, which in turn can affect the TCP11L1's involvement in cell proliferation and differentiation. Similarly, SP600125 can inhibit the JNK pathway, which is also part of the MAPK signaling cascade, leading to an indirect inhibition of the TCP11L1's role in signal transduction processes. Lastly, Y-27632, a selective inhibitor of ROCK kinase, can impact the regulation of cytoskeleton architecture and cell motility, processes in which TCP11L1 is implicated, therefore influencing the functional capacity of TCP11L1 in these cellular mechanisms.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $68.00 $312.00 | 2 | |
Alsterpaullone is known as a cyclin-dependent kinase inhibitor. Given that TCP11L1 is involved in spermatogenesis, and cell cycle regulation is crucial for this process, inhibition of cyclin-dependent kinases by Alsterpaullone can indirectly inhibit the function of TCP11L1 in cell cycle regulation. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
This chemical is a protein kinase C inhibitor. Protein kinase C is integral to various signaling pathways, including those regulating cellular proliferation and differentiation. Inhibition of protein kinase C can indirectly inhibit the functional role of TCP11L1 in these pathways. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
Chelerythrine Chloride is a selective inhibitor of protein kinase C. By inhibiting protein kinase C, this chemical can disrupt signaling pathways where TCP11L1 is involved, potentially inhibiting its functional role in processes like cell communication and spermatogenesis. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $227.00 | 8 | |
Gö6976 is a potent inhibitor of certain isoforms of protein kinase C. If TCP11L1 activity is linked to protein kinase C-mediated signaling, Gö6976 may indirectly inhibit TCP11L1 through the suppression of these pathways, which could be vital for TCP11L1's functional role. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H-89 is known to inhibit protein kinase A. Protein kinase A is involved in multiple cellular processes, including signal transduction and regulation of cell cycle. Inhibition of protein kinase A can indirectly inhibit TCP11L1 by disrupting these critical cellular processes. | ||||||
Indirubin-3′-monoxime | 160807-49-8 | sc-202660 sc-202660A sc-202660B | 1 mg 5 mg 50 mg | $79.00 $321.00 $671.00 | 1 | |
This chemical is an inhibitor of cyclin-dependent kinases. Since TCP11L1 is involved in cellular processes that can be regulated by cyclin-dependent kinases, inhibition by Indirubin-3'-monoxime can consequently inhibit TCP11L1's function in these processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a potent inhibitor of PI3K, a key signal transducer in multiple pathways, including those regulating cell growth and survival. Inhibition of PI3K can indirectly inhibit TCP11L1 by affecting downstream signaling events that TCP11L1 may be involved in. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML7 hydrochloride effectively inhibits myosin light chain kinase. Since TCP11L1 has a role in cellular movement and structure, inhibition of myosin light chain kinase can indirectly inhibit TCP11L1 by affecting the cytoskeletal dynamics and cell motility. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which is upstream of MAPK/ERK signaling. The ERK pathway is implicated in various cellular functions, including proliferation and differentiation. Inhibition of this pathway can thereby indirectly inhibit TCP11L1's functional involvement in these processes. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which is part of the MAPK signaling pathway. By inhibiting JNK, SP600125 can indirectly inhibit TCP11L1 by disrupting JNK-mediated signal transduction processes that could be essential for the functional role of TCP11L1. | ||||||