TBCA Inhibitors
TBCA inhibitors are a class of chemical compounds that target and inhibit tubulin cofactor A (TBCA), an essential protein involved in the regulation of microtubule dynamics. Microtubules are structural components of the cytoskeleton, playing a critical role in cellular processes such as mitosis, intracellular transport, and structural integrity. Tubulin cofactor A is specifically involved in the folding and assembly of alpha- and beta-tubulin, which are the building blocks of microtubules. By inhibiting TBCA, these compounds disrupt the proper assembly of tubulin dimers, leading to alterations in microtubule formation and stability. This has a cascading effect on cellular processes that are reliant on intact and dynamic microtubules, ultimately affecting cell structure, division, and intracellular transport.
The specific mechanisms of action for TBCA inhibitors typically involve binding to the active site or regulatory regions of tubulin cofactor A, preventing it from performing its normal function in tubulin folding. This inhibition can lead to a reduction in the available pool of functional tubulin, resulting in impaired microtubule polymerization. The disruption in microtubule dynamics also impacts other cellular proteins that interact with the cytoskeleton, further amplifying the cellular response. Research into the structural characteristics of TBCA inhibitors has focused on identifying key functional groups and molecular frameworks that enhance their binding affinity and selectivity for TBCA. These studies have highlighted the importance of both hydrophobic interactions and hydrogen bonding in stabilizing the inhibitor-protein complex, providing insight into the design of more potent and specific inhibitors for experimental applications.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium Orthovanadate is a potent inhibitor of protein tyrosine phosphatases. It can indirectly inhibit TBCA by maintaining the phosphorylation status of proteins that TBCA may interact with, thus potentially altering TBCA's function. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent, broad-spectrum kinase inhibitor. It can indirectly affect TBCA function by inhibiting the activity of protein kinases that could regulate TBCA's interacting proteins. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases. By preventing dephosphorylation, it might lead to an altered interaction profile for TBCA, potentially leading to decreased functional activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. It can indirectly inhibit TBCA by preventing tyrosine phosphorylation of proteins that might interact with TBCA. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective MEK inhibitor. By inhibiting MEK, it can reduce the Erk1/2 signaling pathway activity, which could indirectly inhibit TBCA by affecting its protein interaction network. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a potent JNK inhibitor. It inhibits JNK signaling, potentially influencing the functional activity of TBCA by affecting its interaction partners. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. By inhibiting this pathway, it could indirectly influence the functional activity of TBCA via modulation of its protein interaction partners. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. It can indirectly inhibit TBCA function by inhibiting the PI3K/Akt pathway, which may modulate the functional activity of proteins that interact with TBCA. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of Rho-associated protein kinases (ROCK). It can potentially exert indirect inhibitory effects on TBCA by changing the activity status of proteins modulated by the Rho/ROCK pathway. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII). It can indirectly inhibit TBCA by affecting the functional activity of proteins that interact with TBCA and are modulated by the CaMKII pathway. | ||||||