TBCA Activators
TBCA Activators encompass a range of chemical compounds that indirectly facilitate the functional activity of TBCA, primarily through their interactions with microtubules and tubulin, the key elements in cell structure and function that TBCA helps regulate. Microtubule-stabilizing agents such as Paclitaxel, Epothilone B, Taxol, Peloruside A, and Laulimalide enhance TBCA's activity by supporting and maintaining the microtubule structures. The stabilization of these structures underscores the importance of TBCA in tubulin biogenesis and the proper formation of microtubules. By stabilizing microtubules, these compounds enhance the role of TBCA in ensuring the assembly and maintenance of this critical cellular component.
On the other hand, microtubule-disrupting agents like Vinblastine, Colchicine, Vincristine, Nocodazole, Podophyllotoxin, Noscapine, and Griseofulvin increase the cellular demand for functional tubulin, which indirectly boosts TBCA's activity. These compounds disrupt normal microtubule dynamics, leading to a compensatory increase in tubulin folding and stabilization activities where TBCA plays a crucial role. The disruption caused by these agents highlights TBCA's significance in maintaining cell structure and function, particularly in processes reliant on microtubule integrity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules by binding to β-tubulin, enhancing TBCA activity by supporting the microtubule structures it helps form. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine inhibits microtubule assembly, which could indirectly increase TBCA activity by upregulating the cellular need for functional tubulin. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, inhibiting polymerization and potentially leading to enhanced TBCA activity as the cell compensates for disrupted microtubules. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubules, potentially enhancing TBCA activity by altering tubulin dynamics and increasing the need for tubulin folding. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Epothilone B stabilizes microtubules and could enhance TBCA activity by supporting the microtubule structures that TBCA helps establish. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin inhibits tubulin polymerization, potentially increasing the demand for TBCA in tubulin folding and microtubule formation. | ||||||
Noscapine | 128-62-1 | sc-219418 | 10 mg | $102.00 | ||
Noscapine alters microtubule dynamics, potentially enhancing TBCA activity by modifying the equilibrium of tubulin polymerization and depolymerization. | ||||||
Laulimalide | 115268-43-4 | sc-507261 | 100 µg | $200.00 | ||
Laulimalide stabilizes microtubules, potentially enhancing TBCA activity by reinforcing the microtubule structures it assists in forming. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by interacting with tubulin, potentially increasing the need for TBCA in tubulin biogenesis and microtubule formation. | ||||||