TBC1D28 Activators
Forskolin and the cAMP analog 8-Bromo-cAMP exert their effects by raising intracellular cAMP levels, activating protein kinase A (PKA), and potentially influencing TBC1D28's activity through phosphorylation events. Growth factors such as EGF and IGF-1 bind to their respective receptors and activate downstream signaling cascades that could lead to the modulation of TBC1D28. These cascades often involve a series of phosphorylation events that can alter protein function. PMA, by activating protein kinase C (PKC), and A23187, by increasing intracellular calcium levels, can also affect various proteins and pathways that may intersect with the regulatory mechanisms of TBC1D28.
Phosphoinositide 3-kinase (PI3K) is targeted by LY294002, which in turn modulates the AKT signaling pathway, a key regulator of many cellular processes including protein trafficking and apoptosis. The p38 MAPK inhibitor SB203580 and the ROCK inhibitor Y-27632 alter the cell's response to stress and cytoskeletal architecture, respectively, which could have downstream effects on TBC1D28. U73122 disrupts phospholipase C activity, showcasing how inhibition of one signaling molecule can have ripple effects on related proteins and pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which could phosphorylate substrates that modulate TBC1D28 activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
This cAMP analog can activate PKA, which might phosphorylate and alter TBC1D28 activity. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin receptor activation can initiate signaling pathways that may have an effect on TBC1D28. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
This ionophore increases intracellular calcium levels, which can activate signaling pathways affecting TBC1D28. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
This PI3K inhibitor can modulate the PI3K-AKT signaling pathway, potentially affecting TBC1D28. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
This p38 MAPK inhibitor can influence stress response pathways that may intersect with TBC1D28 regulatory mechanisms. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
As a ROCK inhibitor, it can affect cytoskeletal organization and potentially impact TBC1D28's function in cellular trafficking. | ||||||