TAX-2 Inhibitors
Chemical inhibitors of TAX-2 can modulate the signaling pathways and cellular processes in which this protein is involved through various mechanisms. SB-334867 acts as an antagonist of the orexin-1 receptor, which is one of the pathways regulated by TAX-2. By blocking the OX1 receptor, SB-334867 directly impairs the downstream effects mediated by TAX-2 in the orexin signaling pathway. Similarly, BML-260, as a selective inhibitor of diacylglycerol kinase, prevents the conversion of diacylglycerol to phosphatidic acid, thereby affecting the phosphatidylinositol signaling pathway and reducing the signaling activity where TAX-2 functions as a downstream effector. ML-7 targets myosin light chain kinase, which is crucial for actin cytoskeleton regulation. Since TAX-2 is implicated in cytoskeletal organization, inhibition by ML-7 can alter cytoskeletal dynamics and disrupt TAX-2-related cellular processes.
Furthermore, Y-27632, a selective inhibitor of Rho-associated protein kinase, disrupts the Rho/ROCK pathway, where TAX-2 plays a role, potentially affecting TAX-2-mediated cellular responses. Go 6983 and GF 109203X, both inhibitors of protein kinase C, can reduce the phosphorylation of targets in TAX-2 signaling pathways, leading to diminished TAX-2 activity. LY294002 and Wortmannin, which are inhibitors of phosphoinositide 3-kinases, impede the PI3K/Akt signaling pathway, a key route for TAX-2's role in cell regulation. PD98059, an inhibitor of MEK, prevents the activation of the ERK pathway, thereby inhibiting downstream effects mediated by TAX-2. U73122 inhibits phospholipase C, which is pivotal in the inositol phosphate pathway involving TAX-2, decreasing the production of secondary messengers and thus affecting TAX-2 signaling. Lastly, KT5720 and Ro-31-8220 target protein kinase A and protein kinase C respectively, both of which are associated with TAX-2-related pathways, and their inhibition by these chemicals can impair the respective signaling cascades involving TAX-2.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB-334867 | 792173-99-0 | sc-507323 | 10 mg | $207.00 | ||
SB-334867 is an antagonist of the orexin-1 (OX1) receptor, which TAX-2 modulates. Inhibition of OX1 by SB-334867 can impede the downstream effects mediated by TAX-2 in the orexin signaling pathway, leading to a decrease in TAX-2 mediated functions such as neural signaling and inflammation. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK), which is involved in the regulation of the actin cytoskeleton. TAX-2 has been implicated in actin cytoskeleton organization. By inhibiting MLCK, ML-7 could lead to an altered cytoskeletal organization, potentially inhibiting the cellular processes in which TAX-2 participates. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a selective inhibitor of the Rho-associated protein kinase (ROCK). TAX-2 is implicated in pathways that are regulated by the Rho/ROCK signaling. Inhibition of ROCK by Y-27632 may disrupt downstream effects where TAX-2 plays a role, potentially diminishing TAX-2-mediated cellular responses. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Go 6983 is an inhibitor of protein kinase C (PKC). TAX-2 is associated with pathways that involve PKC signaling. By inhibiting PKC, Go 6983 could reduce the phosphorylation of downstream targets involved in TAX-2 signaling pathways, leading to a reduced TAX-2 function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of phosphoinositide 3-kinases (PI3K). TAX-2 operates within PI3K/Akt signaling pathways. Inhibition of PI3K by LY294002 would likely impede the phosphorylation and activation of Akt, subsequently inhibiting downstream processes in which TAX-2 is involved. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of mitogen-activated protein kinase kinase (MEK), which is upstream of extracellular signal-regulated kinase (ERK) signaling. TAX-2 is suggested to play a role in ERK pathway signaling. Inhibition of MEK by PD98059 would prevent ERK activation and subsequent TAX-2 mediated cellular effects. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
GF 109203X, also known as bisindolylmaleimide I, is a potent inhibitor of PKC. This inhibition can reduce TAX-2 related signaling events that are dependent on PKC activity, such as modulation of ion channels and transcription factors. | ||||||
KT 5720 | 108068-98-0 | sc-3538 sc-3538A sc-3538B | 50 µg 100 µg 500 µg | $97.00 $144.00 $648.00 | 47 | |
KT5720 is an inhibitor of protein kinase A (PKA). TAX-2 has been associated with cAMP-dependent PKA signaling pathways. Inhibition of PKA by KT5720 would likely impair cAMP response element-binding protein (CREB) phosphorylation and thus inhibit TAX-2-related signaling events. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $90.00 $240.00 | 17 | |
Ro-31-8220 is a PKC inhibitor with broad specificity. By inhibiting PKC, it can inhibit downstream effects of TAX-2 that are mediated through PKC-dependent signaling pathways, potentially diminishing TAX-2 function in these pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K. By inhibiting PI3K, it would interfere with the TAX-2-related PI3K/Akt signaling pathway, potentially leading to reduced TAX-2 function in processes such as cell survival and metabolism. | ||||||