SB-334867 (CAS 792173-99-0)
Alternate Names:
N-(2-methyl-6-benzoxazolyl)-N′-1,5-naphthyridin-4-yl-urea
CAS Number:
792173-99-0
Molecular Weight:
319.30
Molecular Formula:
C17H13N5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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SB-334867 (CAS 792173-99-0) References
- SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats. | Rodgers, RJ., et al. 2001. Eur J Neurosci. 13: 1444-52. PMID: 11298806
- Orexin receptor type-1 antagonist SB-334867 inhibits the development of morphine analgesic tolerance in rats. | Ranjbar-Slamloo, Y., et al. 2012. Peptides. 35: 56-9. PMID: 22421510
- SB 334867, a selective orexin receptor type 1 antagonist, elevates seizure threshold in mice. | Socała, K., et al. 2016. Life Sci. 150: 81-8. PMID: 26916826
- SB-334867, an orexin receptor 1 antagonist, decreased seizure and anxiety in pentylenetetrazol-kindled rats. | Kordi Jaz, E., et al. 2017. Fundam Clin Pharmacol. 31: 201-207. PMID: 27739093
- The orexin-1 receptor antagonist SB-334867 reduces motivation, but not inhibitory control, in a rat stop signal task. | Wiskerke, J., et al. 2020. Brain Res. 1731: 146222. PMID: 31002819
- Persistent effects of the orexin-1 receptor antagonist SB-334867 on naloxone precipitated morphine withdrawal symptoms and nociceptive behaviors in morphine dependent rats. | Kourosh-Arami, M., et al. 2022. Int J Neurosci. 132: 67-76. PMID: 32746675
- Synergistic antidepressant effects of citalopram and SB-334867 in the REM sleep-deprived mice: Possible role of BDNF. | Saadati, N., et al. 2022. Pharmacol Biochem Behav. 219: 173449. PMID: 35973584
- The effects of citalopram, SB-334867 and orexin-1, alone or in various combinations, on the anxiogenic-like effects of REM sleep deprivation in male mice. | Saadati, N., et al. 2022. Behav Pharmacol. 33: 559-566. PMID: 36165531
- Selective orexin 1 receptor antagonist SB-334867 aggravated cognitive dysfunction in 3xTg-AD mice. | Gao, WR., et al. 2023. Behav Brain Res. 438: 114171. PMID: 36280008
- Blockade of orexin receptor type-1 by SB-334867 and activation of orexin receptor type-2 attenuate morphine tolerance in rats. | Ozdemir, E., et al. 2022. Physiol Int. 109: 457-474. PMID: 36480169
Inhibitor of:
GATA-3, MCH-2R, MrgA2a, Orexin R-1, Orexin R-2, ORMDL3, pro-MCH, QRFP, and TAX-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SB-334867, 10 mg | sc-507323 | 10 mg | $207.00 |