Tau Activators

The chemical class known as Tau activators comprises compounds that can indirectly influence the regulation, phosphorylation, and aggregation of the Tau protein, primarily associated with neurodegenerative disorders. Many of these compounds exert their effects by modulating cellular processes and pathways that are implicated in Tau pathology. For example, Curcumin and Epigallocatechin gallate (EGCG) are polyphenols known for their ability to inhibit Tau aggregation and promote microtubule stability, mitigating Tau-related neurodegeneration.

Other compounds like Lithium and Rapamycin can indirectly affect Tau by targeting pathways associated with Tau phosphorylation and aggregation. Lithium can modulate GSK-3β, an enzyme that phosphorylates Tau, while Rapamycin activates autophagy, which may help clear Tau aggregates. Sodium Selenite, Rolipram, and Withaferin A may impact Tau hyperphosphorylation by targeting oxidative stress pathways, PDE4 inhibition, and GSK-3β, respectively. Berberine is another compound that may reduce Tau hyperphosphorylation and aggregation through various mechanisms. N-Acetyl-L-cysteine (NAC) and Trehalose modulate oxidative stress and enhance autophagy, affecting Tau regulation and clearance of Tau aggregates. Valproic acid, an HDAC inhibitor, can influence Tau acetylation. Finally, Salubrinal may indirectly affect Tau phosphorylation through endoplasmic reticulum (ER) stress pathways. Overall, the chemical class of Tau activators includes diverse compounds that can indirectly impact Tau, offering avenues for research into neurodegenerative disorders.