Tau Inhibitors
Tau inhibitors belong to a class of compounds that play a pivotal role in the modulation of certain cellular processes. These inhibitors are designed to interact with and modulate the activity of tau proteins, which are primarily found in nerve cells (neurons) of the central nervous system. Tau proteins are integral to the stabilization of microtubules, which are essential for maintaining the structural integrity of neurons and facilitating their intracellular transport. By binding to tau proteins, these inhibitors influence their conformation and subsequent interactions, leading to alterations in cellular processes.
The intricate interplay between tau proteins and microtubules highlights the significance of tau inhibitors in cellular physiology. When tau proteins undergo abnormal modifications or aggregations, it can result in disruptions to microtubule function and contribute to cellular dysfunction. The development of tau inhibitors aims to mitigate these disruptions by modulating the behavior of tau proteins, thereby indirectly influencing microtubule dynamics. This class of compounds often undergoes extensive research to uncover their mechanisms of action and their impacts on cellular processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Epothilone D | 189453-10-9 | sc-207630 sc-207630A sc-207630B sc-207630C | 1 mg 25 mg 100 mg 250 mg | $406.00 $988.00 $3121.00 $5202.00 | ||
Stabilizes microtubules by promoting tubulin polymerization, inhibiting tau-microtubule binding. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Promotes microtubule assembly and stability by binding to tubulin, disrupting tau-microtubule interactions. | ||||||
Methylene blue | 61-73-4 | sc-215381B sc-215381 sc-215381A | 25 g 100 g 500 g | $43.00 $104.00 $328.00 | 3 | |
Reduces tau aggregation by interfering with tau fibril formation and stabilizing microtubules. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Modulates glycogen synthase kinase-3β (GSK-3β) activity, impacting tau phosphorylation and aggregation. | ||||||
Tideglusib | 865854-05-3 | sc-507358 | 10 mg | $77.00 | ||
Inhibits GSK-3β, leading to reduced tau phosphorylation and aggregation, and potential neuroprotection. | ||||||
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $33.00 $136.00 $458.00 | 5 | |
Acts as a glutathione peroxidase mimic, reducing oxidative stress and inhibiting tau aggregation. | ||||||
Riluzole | 1744-22-5 | sc-201081 sc-201081A sc-201081B sc-201081C | 20 mg 100 mg 1 g 25 g | $20.00 $193.00 $213.00 $317.00 | 1 | |
Modulates ion channels, dampening excitotoxicity, which may indirectly affect tau phosphorylation. | ||||||